Results 21 to 30 of about 1,053,068 (399)
The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma
miR-372 has been shown a potent oncogenic miRNA in the pathogenesis of oral squamous cell carcinoma (OSCC). The zinc finger and BTB domain containing 7A protein (ZBTB7A) is a transcriptional regulator that is involved in a great diversity of ...
Li-Yin Yeh+15 more
doaj +1 more source
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify the challenges and propose a set of minimal reporting guidelines for mouse and human MDSC ...
V. Bronte+14 more
semanticscholar +1 more source
Firespike leafroll-associated virus (FLRaV) is a major pathogen associated with firespike (Odontonema tubaeforme) leafroll disease. Phylogenetic analysis showed that FLRaV possesses typical traits of subgroup II members of ampeloviruses, but encodes two ...
Yaqin Wang+6 more
doaj +1 more source
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress.
Jean-Philippe Coppé+8 more
semanticscholar +1 more source
The Hippo pathway in disease and therapy: cancer and beyond
The Hippo tumour suppressor pathway co‐ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal inputs on different levels to ensure the ...
Marta Gomez+2 more
doaj +1 more source
The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae. Disruption of the T2SS genes in V.
Chelsea S. Rule+9 more
doaj +1 more source
SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]
Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Fierro Gutierrez, Ana Carolina Elisa+3 more
core +2 more sources
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated that overexpression of PTEN, a putative tumor suppressor, reduced insulin-induced PtdIns(3,4,5)P3 production in human 293 ...
T. Maehama, J. Dixon
semanticscholar +1 more source
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control
The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they
Yavuz Kulaberoglu+14 more
doaj +1 more source
Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC
Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality.
Kelvin Anderson+7 more
doaj +1 more source