Results 21 to 30 of about 1,053,068 (399)

The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma

open access: yesFrontiers in Oncology, 2020
miR-372 has been shown a potent oncogenic miRNA in the pathogenesis of oral squamous cell carcinoma (OSCC). The zinc finger and BTB domain containing 7A protein (ZBTB7A) is a transcriptional regulator that is involved in a great diversity of ...
Li-Yin Yeh   +15 more
doaj   +1 more source

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

open access: yesNature Communications, 2016
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify the challenges and propose a set of minimal reporting guidelines for mouse and human MDSC ...
V. Bronte   +14 more
semanticscholar   +1 more source

P25 and P37 proteins encoded by firespike leafroll-associated virus are viral suppressors of RNA silencing

open access: yesFrontiers in Microbiology, 2022
Firespike leafroll-associated virus (FLRaV) is a major pathogen associated with firespike (Odontonema tubaeforme) leafroll disease. Phylogenetic analysis showed that FLRaV possesses typical traits of subgroup II members of ampeloviruses, but encodes two ...
Yaqin Wang   +6 more
doaj   +1 more source

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

open access: yesPLoS Biology, 2008
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress.
Jean-Philippe Coppé   +8 more
semanticscholar   +1 more source

The Hippo pathway in disease and therapy: cancer and beyond

open access: yesClinical and Translational Medicine, 2014
The Hippo tumour suppressor pathway co‐ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal inputs on different levels to ensure the ...
Marta Gomez   +2 more
doaj   +1 more source

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

open access: yesmSphere, 2020
The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae. Disruption of the T2SS genes in V.
Chelsea S. Rule   +9 more
doaj   +1 more source

SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]

open access: yes, 2015
Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Fierro Gutierrez, Ana Carolina Elisa   +3 more
core   +2 more sources

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate*

open access: yesJournal of Biological Chemistry, 1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated that overexpression of PTEN, a putative tumor suppressor, reduced insulin-induced PtdIns(3,4,5)P3 production in human 293 ...
T. Maehama, J. Dixon
semanticscholar   +1 more source

Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control

open access: yesNature Communications, 2017
The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they
Yavuz Kulaberoglu   +14 more
doaj   +1 more source

Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC

open access: yesFrontiers in Immunology, 2020
Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality.
Kelvin Anderson   +7 more
doaj   +1 more source

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