Results 21 to 30 of about 817,665 (309)
Research Journal of Medical Sciences, 2010 Tumour suppressor genes are a class of genes that have a crucial role in the genesis of neoplasia. These genes when transcribed and translated, result in the production of proteins that regulate the cell cycle, repair any DNA mutations and control apoptosis.
Gamudi, Donia, Blundell, Renald
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Glucose Transporters and Virulence in
mSphere, 2018 Glucose transporters are important for viability and infectivity of the disease-causing amastigote stages of Leishmania mexicana. The Δgt1-3 null mutant, in which the 3 clustered glucose transporter genes, GT1, GT2, and GT3, have been deleted, is ...
Xiuhong Feng +4 more
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The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma
Frontiers in Oncology, 2020 miR-372 has been shown a potent oncogenic miRNA in the pathogenesis of oral squamous cell carcinoma (OSCC). The zinc finger and BTB domain containing 7A protein (ZBTB7A) is a transcriptional regulator that is involved in a great diversity of ...
Li-Yin Yeh +15 more
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The Hippo pathway in disease and therapy: cancer and beyond
Clinical and Translational Medicine, 2014 The Hippo tumour suppressor pathway co‐ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal inputs on different levels to ensure the ...
Marta Gomez +2 more
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Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control
Nature Communications, 2017 The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they
Yavuz Kulaberoglu +14 more
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mSphere, 2020 The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae. Disruption of the T2SS genes in V.
Chelsea S. Rule +9 more
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SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]
, 2015 Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Fierro Gutierrez, Ana Carolina Elisa +3 more
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Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC
Frontiers in Immunology, 2020 Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality.
Kelvin Anderson +7 more
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Frontiers in Microbiology, 2022 Firespike leafroll-associated virus (FLRaV) is a major pathogen associated with firespike (Odontonema tubaeforme) leafroll disease. Phylogenetic analysis showed that FLRaV possesses typical traits of subgroup II members of ampeloviruses, but encodes two ...
Yaqin Wang +6 more
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Frontiers in Microbiology, 2018 The proper timing and positioning of cytokinesis/septation is crucial for hyphal growth and conidiation in Aspergillus nidulans. The septation initiation network (SIN) components are a conserved spindle pole body (SPB) localized signaling cascade and the
Ping Jiang, Shujun Zheng, Ling Lu
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