Results 51 to 60 of about 526,009 (268)

Expression of Tumor Suppressor SFRP1 Predicts Biological Behaviors and Prognosis: A Potential Target for Oral Squamous Cell Carcinoma [PDF]

, 2022
Chun Chen, Yifei Zhang, Yupeng Liu, Lei Hang, Jun Yang   +4 more
openalex   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

Cell Reports, 2019
Summary: In addition to oncogene inhibition, targeting tumor suppressor deficiency could provide potential venues for precision cancer medicine. However, the full spectrum of drug vulnerability conferred by tumor suppressor loss remains unclear.
Hongyu Ding, Jie Zhao, Yanli Zhang, Jiao Yu, Mingxian Liu, Xiaoxi Li, Liang Xu, Minghui Lin, Chuan Liu, Zhengjin He, Shishuang Chen, Hai Jiang   +11 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Identification of RNA silencing suppressor encoded by citrus chlorotic dwarf-associated virus

Frontiers in Microbiology
IntroductionCitrus chlorotic dwarf-associated virus (CCDaV) is an economically important citrus virus associated with leaf curling, deformation, and chlorosis found in China.
Xiao Ye, Dongdong Ding, Yuan Chen, Chuang Liu, Zhongan Li, Binghai Lou, Yan Zhou   +6 more
doaj   +1 more source

Suppressor genes as molecular markers of colorectal cancer – a review of the latest reports

Studia Medyczne, 2020
Suppressor gene research is one of the main current trends in modern cancer research. Oncogenesis, including colorectal cancer (CRC), is a process strictly dependent on the proper functioning of the suppressor genes and their proteins.
Agnieszka Piechowska, Monika Wawszczak, Anna Cedro, Stanisław Głuszek   +3 more
doaj   +1 more source

Conformational Heterogeneity and Frustration of the Tumor Suppressor p53 as Tuned by Punctual Mutations [PDF]

, 2022
Anna Rita Bizzarri
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Myeloid-derived suppressor cells and their role in gynecological malignancies

Tumor Biology, 2018
Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells).
Seiji Mabuchi, Eriko Yokoi, Naoko Komura, Tadashi Kimura   +3 more
doaj   +1 more source