Results 121 to 130 of about 189,911 (333)

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

[Role of the cytokine-3 signaling suppressor protein (SOCS 3) in growth hormone resistance induced by malnutrition].

Biomedica : revista del Instituto Nacional de Salud, 2004
Nutrition is an important regulator of growth hormone (GH) action. Nutritional deprivation causes a GH resistance involving post-receptor alterations in the signaling pathway, but the responsible mechanisms remain unknown. Herein, suppressors of cytokine signaling proteins (SOCS) were investigated as potential agents in GH-resistance induced by ...
Adriana, Umaña, Stella, Carrasco, Myriam, Sánchez   +2 more
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy

Experimental and Molecular Medicine
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of Prmt7 in protecting against menopause-associated cardiomyopathy. Mice with cardiac-specific Prmt7 ablation
Byeong-Yun Ahn, Yan Zhang, Shibo Wei, Yideul Jeong, Dong-Hyun Park, Sang-Jin Lee, Young-Eun Leem, Jong-Sun Kang   +7 more
doaj   +1 more source

Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cardiac remodeling is a critical pathogenetic process leading to heart failure. Suppressor of cytokine signaling-3 (SOCS3) is demonstrated as a key negative regulator of the gp130 receptor to inhibit cardiac hypertrophy.
Shuang Liu, Li-Xin Liu, Yun-Long Zhang, Song Lai, Yun-Peng Xie, Nan-Nan Li, Hong-Xia Wang, Yun-Long Xia, Ying Liu, Hui-Hua Li   +9 more
doaj   +1 more source

MicroRNAs in lung cancer [PDF]

, 2017
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this ...
An, Baltimore, Belinsky, Brennan, Chen, De Flora, De Flora, Dong, Duan, Gomez, Hao, Harris, Hasegawa, Haugen, Hu, Inoue, Jemal, Jia, Lam, Li, Liu, Nakanishi, Neilson, O'Driscoll, Pan, Peiper, Ren, Schmeck, Schrump, Sensinger, Shah, Slack, Speiser, Stampfli, Wang, Wang, Yoshida, You, Zhang, Zhang, Zienolddiny   +40 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]

, 2015
Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
core   +1 more source

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Diabetes, 2010
OBJECTIVE Hypothalamic leptin resistance is found in most common forms of obesity, such as diet-induced obesity, and is associated with increased expression of suppressor of cytokine signaling 3 (Socs3) in the hypothalamus of diet-induced obese animals ...
Alison S. Reed, Elizabeth K. Unger, Louise E Olofsson, M. Piper, M. Myers, Allison W. Xu   +5 more
semanticscholar   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source