Results 21 to 30 of about 189,911 (333)

Heat Shock Protein 60 Activates Cytokine-Associated Negative Regulator Suppressor of Cytokine Signaling 3 in T Cells: Effects on Signaling, Chemotaxis, and Inflammation1 [PDF]

The Journal of Immunology, 2005
Abstract Previously, we reported that treatment of T cells with the 60-kDa heat shock protein (HSP60) inhibits chemotaxis. We now report that treatment of purified human T cells with recombinant human HSP60 or its biologically active peptide p277 up-regulates suppressor of cytokine signaling (SOCS)3 expression via TLR2 and STAT3 ...
A. Zanin-Zhorov, G. Tal, Shoham Shivtiel, Michal Cohen, T. Lapidot, G. Nussbaum, R. Margalit, I. Cohen, O. Lider   +8 more
semanticscholar   +3 more sources

The mechanism of oxymatrine on atopic dermatitis in mice based on SOCS1/JAK-STAT3 pathway

Frontiers in Pharmacology, 2023
Based on the suppressor of cytokine signaling 1 (SOCS1)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway, the mechanism of oxymatrine in the treatment of atopic dermatitis (AD) was preliminarily explored in this study.
Xianwei Han, Tianming Ma, Qiang Wang, Chunlin Jin, Yusheng Han, Guijun Liu, Hao Li   +6 more
doaj   +1 more source

Effect of (−)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A

Toxins, 2021
Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. Gp130 activates intracellular signaling pathways, including the Janus kinase/signal transducers and activators of transcription (JAK/STAT ...
Yuko Shimamura, Rina Noaki, Ami Kurokawa, Mio Utsumi, Chikako Hirai, Toshiyuki Kan, Shuichi Masuda   +6 more
doaj   +1 more source

Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells.

PLoS Pathogens, 2023
Congenital human cytomegalovirus (HCMV) infection causes severe damage to the fetal brain, and the underlying mechanisms remain elusive. Cytokine signaling is delicately controlled in the fetal central nervous system to ensure proper development. Here we
Xian-Zhang Wang, Le Wen, Yue-Peng Zhou, Sheng-Nan Huang, Bo Yang, Shuang Cheng, Wen-Bo Zeng, Meng-Jie Mei, Jin-Yan Sun, Xuan Jiang, Han Cheng, Min-Hua Luo   +11 more
doaj   +1 more source

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3.

Journal of Allergy and Clinical Immunology, 2013
In patients with persistent upper airway inflammation, the number of forkhead box protein 3 (Foxp3)(+) regulatory T (Treg) cells is reduced, but the regulation of Foxp3 expression in Treg cells is poorly understood.We investigated the interaction between suppressor of cytokine signaling 3 (SOCS3) and Foxp3 expression in the airway mucosa.Expression of ...
F. Lan, N. Zhang, Jie Zhang, O. Krysko, Quanbo Zhang, J. Xian, L. Derycke, Yanyu Qi, Kai Li, Shixi Liu, P. Lin, C. Bachert   +11 more
semanticscholar   +3 more sources

The Role of Differentially Expressed miRNAs and Potential miRNA-mRNA Regulatory Network in Prostate Cancer Progression and Metastasis [PDF]

, 2020
Purpose: Aberrant expression of microRNAs (miRNAs) has been discovered in prostate cancer progression however their function is not well understood, thereby further investigation is required to understand the importance of underlying mechanisms and their
Arisan, E.D., Arisan, E.D., Freitas, I.L., Freitas, I.L., Pazoki, K., Pazoki, K., Rahim, S., Rahim, S., Uysal Onganer, P., Uysal Onganer, P.   +9 more
core   +1 more source

Burkholderia pseudomallei-Induced Expression of Suppressor of Cytokine Signaling 3 and Cytokine-Inducible Src Homology 2-Containing Protein in Mouse Macrophages: a Possible Mechanism for Suppression of the Response to Gamma Interferon Stimulation [PDF]

Infection and Immunity, 2005
ABSTRACTBurkholderia pseudomallei, the causative agent of melioidosis, is a facultative intracellular gram-negative bacterium that is able to survive and multiply in macrophages. Previously, we reported thatB. pseudomalleiwas able to escape macrophage killing by interfering with the expression of inducible nitric oxide synthase (iNOS).
P. Ekchariyawat, S. Pudla, K. Limposuwan, S. Arjcharoen, Stitaya Sirisinha, P. Utaisincharoen   +5 more
semanticscholar   +3 more sources

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

Cell Death and Disease, 2022
Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu   +10 more
doaj   +1 more source

Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control. [PDF]

PLoS Computational Biology, 2007
Directing stem cell fate requires knowledge of how signaling networks integrate temporally and spatially segregated stimuli. We developed and validated a computational model of signal transducer and activator of transcription-3 (Stat3) pathway kinetics ...
Alborz Mahdavi, Ryan E Davey, Patrick Bhola, Ting Yin, Peter W Zandstra   +4 more
doaj   +1 more source

Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3. [PDF]

PLoS ONE, 2012
The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor Signal Transducer and Activator of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulating ...
Keun W Park, Susan E Nozell, Etty N Benveniste   +2 more
doaj   +1 more source