Results 301 to 310 of about 189,911 (333)

Overexpression of signal transducer and activator of transcription (STAT-3 and STAT-5) transcription factors and alteration of suppressor of cytokine signaling (SOCS-1) protein in prostate cancer

Journal of Receptors and Signal Transduction, 2012
Prostate cancer is a leading cause of mortality in men worldwide especially in developing countries like India. The molecular mechanisms of the oncogenic signaling pathway(s) that are involved in prostate carcinogenesis play a crucial role in disease progression and persistence.
Neha, Singh, Showket, Hussain, Mausumi, Bharadwaj, Nandita, Kakkar, S K, Singh, Ranbir C, Sobti   +5 more
openaire   +2 more sources

The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin–Beck disease

Biomarkers, 2016
We aimed to verify the levels of IGFBP2 and SOCS3 in cartilage and chondrocytes of Kashin-Beck disease (KBD) patients and the effects of different selenium concentrations on the protein expression levels. Chondrocytes were cultured with sodium selenite in vitro.
Sen, Wang, Chen, Duan, Huan, Liu, Wanzhen, Shao, Cuiyan, Wu, Jing, Han, Xiong, Guo   +6 more
openaire   +2 more sources

Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins

Protein Expression and Purification, 2002
To prepare reagents for a study of the interactions of prolactin (PRL) and growth hormone (GH) receptors (Rs) with suppressor of cytokine signaling (SOCS) proteins in living cells by fluorescence resonance energy transfer methodology, the respective proteins were tagged with cyan (CFP) or yellow (YFP) fluorescent protein.
Liora, Ben-Yair, Rita, Slaaby, Asael, Herman, Yael, Cohen, Eva, Biener, Nava, Moran, Akihiko, Yoshimura, Jonathan, Whittaker, Pierre, De Meyts, Brian, Herman, Arieh, Gertler   +10 more
openaire   +2 more sources

Respiratory Syncytial Virus Proteins Modulate Suppressors of Cytokine Signaling 1 and 3 and the Type I Interferon Response to Infection by a Toll-Like Receptor Pathway

Viral Immunology, 2009
Respiratory syncytial virus (RSV) is a common cause of repeat infections throughout life and potentially severe lower respiratory tract illness in infants, young children, and the elderly. RSV proteins have been shown to contribute to immune evasion by several means, including modification of cytokine and chemokine responses whose expression is ...
Christine M, Oshansky, Thomas M, Krunkosky, Jamie, Barber, Les P, Jones, Ralph A, Tripp   +4 more
openaire   +2 more sources

Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal.

European cytokine network, 2002
We have recently shown that IL-10 represents an efficient stimulus for suppressor of cytokine signalling (SOCS)-3 mRNA expression in human neutrophils and PBMC. Herein, we identify cAMP-elevating agents such as prostaglandin E2 (PGE2), PGE1, forskolin, dibutyryl cAMP (dbcAMP) and cholera toxin as a novel class of agonists able to induce SOCS-3 mRNA and
S. Gasperini, L. Crepaldi, CALZETTI, Federica, L. Gatto, C. Berlato, BAZZONI, Flavia, A. Yoshimura, CASSATELLA, Marco Antonio   +7 more
openaire   +3 more sources

Growth Hormone Down-Regulation of Interleukin-1?? and Interleukin-6 Induced Acute Phase Protein Gene Expression is Associated with Increased Gene Expression of Suppressor of Cytokine Signal-3

Shock, 2003
Severe burn induces the hepatic acute phase response. We previously showed that recombinant human growth hormone (GH) treatment after burn down-regulated acute phase protein (APP) production and gene expression in vivo. In this study, we hypothesized that the inhibitory effect of GH on the hepatic acute phase response was due to increased suppressor of
Xiaowu, Wu, David N, Herndon, Steven E, Wolf   +2 more
openaire   +2 more sources

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Ca-A Cancer Journal for Clinicians, 2023
Balazs Dome
exaly  

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Nature Reviews Immunology, 2021
Filippo Veglia, Dmitry I Gabrilovich
exaly  

miR-522 Modulated the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases Partly via Targeting Suppressor of Cytokine Signaling 3 in Rheumatoid Arthritis Synovial Fibroblasts

DNA and Cell Biology, 2018
Xin Wang, Xu-wei Si, Jiaying Sun, Lixia Yue, Jiajia Wang, Zhong-ming Yu   +5 more
semanticscholar   +1 more source

Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

Signal Transduction and Targeted Therapy, 2021
Kai Li, Benxia Zhang, Xue-Jin Ou
exaly