Results 51 to 60 of about 189,911 (333)

Socs3a is Dispensable for Zebrafish Hematopoiesis and is Required for Neuromast Formation

Frontiers in Bioscience-Landmark
Background: Suppressor of cytokine signaling (SOCS)3 is a regulatory protein that participates in an important negative feedback loop downstream of several critical cytokines, especially members of the interleukin-6 (IL-6) family. As a
Mohamed Luban Sobah, Clifford Liongue, Alister C. Ward   +2 more
doaj   +1 more source

Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. [PDF]

PLoS Pathogens, 2008
The type I interferon (IFN) system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response.
Eva-K Pauli, Mirco Schmolke, Thorsten Wolff, Dorothee Viemann, Johannes Roth, Johannes G Bode, Stephan Ludwig   +6 more
doaj   +1 more source

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]

, 2016
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana, Demir, Ihsan Ekin, Diakopoulos, Kalliope Nina, Einwächter, Henrik, Heikenwälder, Mathias, Kehl, Timo, Korneeva, Olga, Lesina, Marina, Morton, Jennifer, Sansom, Owen J., Saur, Dieter, Schmid, Roland Michael, Sipos, Bence, Sperveslage, Jan, Steiner, Jörg Manfred, Wang, Timothy Cragin, Wimmer, Margit, Wörmann, Sonja Maria   +17 more
core   +1 more source

Newcastle Disease Virus Nonstructural V Protein Upregulates SOCS3 Expression to Facilitate Viral Replication Depending on the MEK/ERK Pathway

Frontiers in Cellular and Infection Microbiology, 2019
Newcastle disease virus (NDV) causes serious economic losses to the poultry industry. In our previous study, we found that NDV induced a strong innate immune response in the chicken embryo and bursa of Fabricius (BF).
Xiangwei Wang, Yanqing Jia, Juan Ren, Na Huo, Haijin Liu, Sa Xiao, Xinglong Wang, Zengqi Yang   +7 more
doaj   +1 more source

Expansion of CD25-Negative Forkhead Box P3-Positive T Cells during HIV and Mycobacterium tuberculosis Infection [PDF]

, 2017
Tuberculosis (TB) and HIV alter the immune system, and coinfected (HIV-TB) individuals usually present deregulations of T-lymphocytic immune response.
Ameri, Diego, Angerami, Matias, Ben, Graciela, Laufer, Natalia Lorna, Perez, Hector, Quiroga, María Florencia, Salomon, Horacio Eduardo, Sued, Omar Gustavo, Suárez, Guadalupe Verónica, Vecchione, María Belén   +9 more
core   +2 more sources

Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes*

Journal of Biological Chemistry, 2003
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines implicated in insulin resistance during infection, cachexia, and obesity. We recently demonstrated that IL-6 inhibits insulin signaling in hepatocytes (Senn, J. J., Klover, P. J., Nowak, I.
J. Senn, P. Klover, I. Nowak, T. Zimmers, L. Koniaris, R. Furlanetto, R. Mooney   +6 more
semanticscholar   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats

Molecular Pain, 2017
Background Cancer-induced pain (CIP) is one of the most severe types of chronic pain with which clinical treatment remains challenging and the involved mechanisms are largely unknown.
Jinrong Wei, M. Li, Dieyu Wang, Hongyan Zhu, Xiangpeng Kong, Shusheng Wang, Youlang Zhou, Zhong Ju, Guang-Yin Xu, G. Jiang   +9 more
semanticscholar   +1 more source

Exploring the Lipid-lowering Effects of Rosa roxburghii Tratt. Alcohol Extract on Diet-induced Obesity Rats through Hepatic Leptin Resistance Pathway

Shipin gongye ke-ji
Objective: To investigate the dose-dependent lipid-lowering effects of Rosa roxburghii Tratt. alcohol extract in diet-induced obese (DIO) rats and examine its regulatory mechanisms through the hepatic leptin signaling pathway.
Yi SUI, Tian LU, Minggang TENG, Chaochen YUE, Li YANG, Huifang CHAI   +5 more
doaj   +1 more source

Post-TTM Rebound Pyrexia after Ischemia-Reperfusion Injury Results in Sterile Inflammation and Apoptosis in Cardiomyocytes [PDF]

, 2019
Introduction. Fever is frequently observed after acute ischemic events and is associated with poor outcome and higher mortality. Targeted temperature management (TTM) is recommended for neuroprotection in comatose cardiac arrest survivors, but pyrexia ...
Berger, Felix, Garlen, Nalina N. A. von, Krech, Jana, Lam, Phuong D., Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +6 more
core   +1 more source