Results 71 to 80 of about 189,911 (333)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Possible integrative actions of leptin and insulin signaling in the hypothalamus targeting energy homeostasis

Frontiers in Endocrinology, 2016
Obesity has emerged as one of the most burdensome conditions in modern society. In this context, understanding the mechanisms controlling food intake is critical.
Mina Thon, Toru Hosoi, Koichiro Ozawa
doaj   +1 more source

Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line*

Journal of Biological Chemistry, 2015
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor-α (TNF-α).
M. Ruscica, Chiara Ricci, C. Macchi, P. Magni, R. Cristofani, Jingwen Liu, A. Corsini, N. Ferri   +7 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts

Allergology International, 2019
Background: Bronchial asthma is a chronic airway disease characterized by eosinophilic airway inflammation. Lung fibroblasts activated by IL-13 serve as important sources of chemokines, such as eotaxins, contributing to persistent eosinophilic ...
Hideyuki Takeshima, Masafumi Horie, Yu Mikami, Kosuke Makita, Naoya Miyashita, Hirotaka Matsuzaki, Satoshi Noguchi, Hirokazu Urushiyama, Yoshihisa Hiraishi, Akihisa Mitani, Zea Borok, Takahide Nagase, Yasuhiro Yamauchi   +12 more
doaj   +1 more source

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. [PDF]

, 2005
Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers within epithelial cell junctions and neuronal synapses. Here, we
Miceli, M Carrie, Patel, Viresh, Round, June L, Schoenberger, Stephen P, Tomassian, Tamar, Zhang, Min   +5 more
core  

MicroRNA-155 expression is independently predictive of outcome in chordoma. [PDF]

, 2015
BackgroundChordoma pathogenesis remains poorly understood. In this study, we aimed to evaluate the relationships between microRNA-155 (miR-155) expression and the clinicopathological features of chordoma patients, and to evaluate the functional role of ...
Choy, Edwin, Duan, Zhenfeng, Hornicek, Francis J, Kelly, Andrew D, Mankin, Henry J, Osaka, Eiji, Shen, Jacson K, Spentzos, Dimitrios, Yang, Pei, Yang, Xiaoqian   +9 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Manassantin A and B From Saururus chinensis Inhibit Interleukin-6–Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells

Journal of Pharmacological Sciences, 2011
Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis ...
Jong Sun Chang, Seung Woong Lee, Myo Sun Kim, Bo Ra Yun, Mi Hye Park, Seok-Geun Lee, Su-Jin Park, Woo Song Lee, Mun-Chual Rho   +8 more
doaj   +1 more source

Tumor-stroma interactions influence the response to PI3K targeted agents in preclinical models of colorectal cancer (CRC) [PDF]

, 2019
Introduction: One of the main obstacle to the successful development of therapeutic strategies remains the identification of biomarker underlying drug resistance. Recently, investigators have become more aware the role of the tumor microenvironment (TME)
Bazzichetto, Chiara
core