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4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy [PDF]
Nature CommunicationsProgressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by abnormal accumulation of the protein tau in the brain, leading to motor and cognitive symptoms that vary between individuals. The reasons for this clinical heterogeneity
Ivan Martinez-Valbuena +21 more
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Progressive supranuclear palsy [PDF]
Seminars in Neurology, 2001 Unfortunately, no drug treatment has been shown to benefit patients with progressive supranuclear palsy (PSP) more than modestly or briefly. The multiplicity of neuronal systems and synaptic physiologies that degenerate in this disorder makes a neurotransmitter-specific approach, such as neurotransmitter replacement or reuptake inhibition, unlikely to ...
K, Tawana, D B, Ramsden
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Progressive supranuclear palsy [PDF]
Postgraduate Medical Journal, 2000 Abstract Progressive supranuclear palsy (PSP) or Steele-Richardson-Olszewski syndrome is a neurodegenerative disease of middle and late age. It is under-diagnosed not only by general physicians but also by neurologists. The cause of PSP is not known.
, Lowrey, , Wong
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Clinical Features of Patients With Progressive Supranuclear Palsy in an US Insurance Claims Database
Frontiers in Neurology, 2021 Background: Progressive supranuclear palsy is a rare neurodegenerative movement disorder and little is known about its epidemiology.Objective: Estimate age-adjusted prevalence of progressive supranuclear palsy and describe antecedent diagnoses and ...
Emma Viscidi +11 more
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Journal of Medical Case Reports, 2021 Background Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy.
Huiping Li +7 more
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Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy
NeuroImage: Clinical, 2021 Progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex.
Irene Sintini +12 more
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Diagnostics, 2022 Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) are clinical manifestations of tauopathic Parkinsonian syndromes. Due to their overlapping symptomatology, the differential diagnosis of these entities may be difficult when ...
Piotr Alster +6 more
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Progressive supranuclear palsy
Hospital Medicine, 2003 Progressive supranuclear palsy, also known as Steele–Richardson–Olszewski syndrome, is an uncommon neurodegenerative parkinsonian disorder that starts in middle and late life, and is frequently misdiagnosed as Parkinson's disease. This review will cover the epidemiology, clinical picture, differential diagnosis and management of patients with ...
Douglas G. Cole, Nutan Sharma
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9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease
NeuroImage: Clinical, 2017 Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey +12 more
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Genetics of Progressive Supranuclear Palsy [PDF]
Journal of Movement Disorders, 2015 Progressive supranuclear palsy (PSP) is a neurodegenerative syndrome that is clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism and cognitive decline.
Sun Young Im +2 more
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