Results 51 to 60 of about 459,381 (230)

Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders

Movement Disorders, EarlyView.
Abstract Background Excessive daytime sleepiness (EDS) is a disabling symptom of Lewy body disorders (LBD). The hypothalamus is a key sleep–wake regulator and is involved in Lewy pathology, but its contribution to EDS in LBD remains unclear. Objectives To use diffusion‐weighted magnetic resonance imaging (MRI) to detect hypothalamic microstructure and ...
Jesse S. Cohen, Hamsanandini Radhakrishnan, Christopher A. Olm, Sandhitsu R. Das, Philip A. Cook, David A. Wolk, Daniel Weintraub, David J. Irwin, Corey T. McMillan   +8 more
wiley   +1 more source

Early positive tactile stimulation reverses the increase of anxiety and decrease of sociality induced by early chronic mechanical pain in mandarin voles

Integrative Zoology, EarlyView.
This study used a tail‐pinching model during development to simulate mechanical pain experienced by pups in high‐social mandarin voles (Microtus mandarinus). Subsequently, brush‐like positive tactile stimuli were applied to the backs of the mandarin voles.
Yahan SUN, Jiayu XIAO, Luoman LI, Haiwei NIU, Yiting ZHU, Lu LI, Wei QIAN, Yin LI, Lizi ZHANG, Yishan QU, Yuting BAI, Xiao HAN, Kaizhe HUANG, Zhixiong HE, Fadao TAI   +14 more
wiley   +1 more source

c-Fos expression in the supraoptic nucleus is the most intense during different durations of restraint water-immersion stress in the rat

Journal of Physiological Sciences, 2009
Restraint water-immersion stress (RWIS) can induce anxiety, hypothermia, and severe vagally-mediated gastric dysfunction. The present work explored the effects of different durations of RWIS on neuronal activities of the forebrain by c-Fos expression in ...
Yu-Yu Zhang, Wen-xing Zhu, Guo-Hong Cao, X. Cui, H. Ai   +4 more
semanticscholar   +1 more source

Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early‐life adversity

Alcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman, Linda Ellis, Amanda Chao, Cecilia Mitchell, Charlis Raineki, Joanne Weinberg   +5 more
wiley   +1 more source

Alpha-synuclein expression in oxytocin neurons of young and old bovine brains

The Journal of Reproduction and Development
Understanding of central nervous system mechanisms underlying age-related infertility remains limited. Fibril α-synuclein, distinct from its monomeric form, is implicated in age-related diseases. Notably, fibril α-synuclein spreads among neurons,
Yvan Bienvenu NIYONZIMA, Yuuki ASATO, Hiroya KADOKAWA   +2 more
doaj   +1 more source

Electrophysiology of hypothalamic magnocellular neurons in vitro: a rhythmic drive in organotypic cultures and acute slices

Frontiers in Neuroscience, 2016
Hypothalamic neurohormones are released in a pulsatile manner. The mechanisms of this pulsatility remain poorly understood and several hypotheses are available, depending upon the neuroendocrine system considered.
Jean-Marc eIsrael, Jean-Marc eIsrael, Stéphane H Oliet, Stéphane H Oliet, Philippe eCiofi, Philippe eCiofi   +5 more
doaj   +1 more source

STUDY OF UNITARY ACTIVITY IN THE SUPRAOPTIC NUCLEUS OF THE HYPOTHALAMUS

The Japanese Journal of Physiology, 1963
Activity in hypothalamic supraoptic nuclear cells was recorded with microelectrodes in hemispherectomized, chloralose-anesthetized cats. Repetitive stimulations of skin afferents augmented activity of some units but inhibited others. Activity of units was little affected by decortication and removal of the caudate nucleus but considerably increased by ...
Isamu Suda, Kiyomi Koizumi, Chandler C. Brooks   +2 more
openaire   +4 more sources

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, Volume 12, Issue 23, June 20, 2025.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. [PDF]

PLoS ONE, 2016
Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no functional evidence linking steroid receptor coactivator-1 to the regulation of blood pressure. We
Antentor Othrell Hinton, Yongjie Yang, Ann P Quick, Pingwen Xu, Chitra L Reddy, Xiaofeng Yan, Corey L Reynolds, Qingchun Tong, Liangru Zhu, Jianming Xu, Xander H T Wehrens, Yong Xu, Anilkumar K Reddy   +12 more
doaj   +1 more source

Ultrastructural localization of GABA in the supraoptic nucleus and neural lobe [PDF]

Neuroscience, 1987
Antibodies directed against the neurotransmitter gamma-aminobutyric acid (GABA) enabled the ultrastructural localization of GABA in conventional glutaraldehyde fixed and osmium postfixed material of the rat supraoptic nucleus and neural lobe. GABA was visualized using immunogold postembedding staining in axonal profiles that terminate on dendrites ...
Michel Geffard, E.H.S. Van Vulpen, R.M. Buijs   +2 more
openaire   +3 more sources