Results 51 to 60 of about 120,576 (303)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The influence of free long wave generation on the shoaling of forced infragravity waves [PDF]

, 2019
Different conceptual models for forced infragravity (long) waves exist in the literature, which suggest different models for the behavior of shoaling forced waves and the possible radiation of free long waves in that process. These are discussed in terms
Bowen, Mansard, Mei, Molin, Moura, Nagase, Phillips, Smith, Van Dongeren   +8 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Surf Zone Turbulence and Suspended Sediment Dynamics—A Review

Journal of Marine Science and Engineering, 2021
The existence of sandy beaches relies on the onshore transport of sand by waves during post-storm conditions. Most operational sediment transport models employ wave-averaged terms, and/or the instantaneous cross-shore velocity signal, but the models ...
Troels Aagaard, Joost Brinkkemper, Drude F. Christensen, Michael G. Hughes, Gerben Ruessink   +4 more
doaj   +1 more source

Near-bed hydrodynamics and turbulence below a large-scale plunging breaking wave over a mobile barred bed profile [PDF]

, 2016
Funded by The research presented in this paper is part of the SINBAD project.
Caceres, I, Hurther, D., O'Donoghue, T, Ribberink, J. S., Van Der A, D A, Van Der Zanden, J.   +5 more
core   +8 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Role of Infragravity Waves in Near-Bed Cross-Shore Sediment Flux in the Breaker Zone

Journal of Marine Science and Engineering, 2014
Results from a series of field experiments, conducted to investigate the influence of infragravity waves (from wave groups), ripple type and location relative to the breaker line on cross-shore suspended sediment flux close to the sea bed in nearshore ...
Samantha Kularatne, Charitha Pattiaratchi   +1 more
doaj   +1 more source

A Coupled Hydrodynamic-Equilibrium Type Beach Profile Evolution Model

Journal of Marine Science and Engineering, 2021
An equilibrium beach profile model is developed and coupled with a parametric hydrodynamic model to provide feedback between the evolving morphology and the hydrodynamics.
Florent Birrien, Tom Baldock
doaj   +1 more source

WAVE CHARACTERISTICS IN THE SURF ZONE

Coastal Engineering Proceedings, 1978
The equations describing conservation of mass, momentum and energy in a turbulent free surface flow are derived for a controle volume extending over the whole depth. The effect of the turbulent surface oscillations are discussed but neglected in the following analysis, where the equations are applied to the energy balance in a surf zone wave motion ...
I. A. Svendsen, P. Å. Madsen, J. Buhr Hansen   +2 more
openaire   +2 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source