Journal of Experimental Medicine, 1951 A study was made of the relationship of blood lipids to the development of experimental atherosclerosis. Rabbits fed a diet containing cholesterol were found to develop hyperlipemia characterized by a great increase in blood cholesterol and a much lesser
A. Kellner, J. Correll, A. T. Ladd
semanticscholar +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Quaternary ammonium salts based on caprylic acid as antimicrobial and surface-active agents. [PDF]
RSC Adv, 2023 Wojcieszak M +4 more
europepmc +1 more source
Quantifying surfactant interaction effects on soil moisture and turf quality [PDF]
, 2009 Soil water repellency occurs widely in horticultural and agricultural soils when very dry. The gradual accumulation and breakdown of surface organic matter over time produces wax-like organic acids, which coat soil particles preventing uniform entry of ...
Bauer, B., Duff, A.A., Poulter, R.E.
core +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment. [PDF]
Sci Rep, 2022 Miyaji H +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Self-healing of concrete cracks by the release of embedded water repellent agents and corrosion inhibitors to reduce the risk for reinforcement corrosion [PDF]
, 2017 From the worldwide steel production, approximately 50 per cent is required to replace corroded steel [1]. In the case of reinforced concrete structures, corrosion of the reinforcement steel causes crack formation and spalling which leads to ...
De Belie, Nele +5 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
wiley +1 more source
Development of highly porous calcium phosphate bone cements applying nonionic surface active agents. [PDF]
RSC Adv, 2021 Cichoń E +4 more
europepmc +1 more source