Results 91 to 100 of about 5,747,403 (195)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Geometric and nongeometric contributions to the surface anomalous Hall conductivity [PDF]

, 2018
A static electric field generates circulating currents at the surfaces of a magnetoelectric insulator. The anomalous Hall part of the surface conductivity tensor describing such bound currents can change by multiples of e(2)/h depending on the insulating
Souza, Ivo, Rauch, Tomas, Olsen, Thomas, Vanderbilt, David   +3 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Electrodynamics of Carbon Nanotubes with Non-Local Surface Conductivity

Applied Sciences
A new framework that can be utilized for the electrodynamics of carbon nanotubes (CNTs) with non-local surface conductivity (spatial dispersion) is presented.
Tomer Berghaus, Touvia Miloh, Oded Gottlieb, Gregory Ya. Slepyan   +3 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

(Fig 9) Conductivity and susceptibility of surface sediment from the Mittelgrund, Eckernförde Bay

, 2011
(Fig 9) Conductivity and susceptibility of surface sediment from the Mittelgrund, Eckernförde ...
Hamer, Kay, Kay Hamer (6974093), von Dobeneck, Tilo, Müller, Hendrik, Tilo von Dobeneck (6965342), Wiebke Nehmiz (6974090), Hendrik Müller (6971357), Nehmiz, Wiebke   +7 more
core   +1 more source

Thermal Conductivity of Water Based Nanofluids Containing Decorated Multi Walled Carbon Nanotubes with Different Amount of TiO2 Nanoparticles [PDF]

Iranian Journal of Chemical Engineering, 2015
In this paper, we report for the first time, thermal conductivity behavior of nanofluids containing decorated MWCNTs with different amount of TiO2 nanoparticles.
S. Abbasi, S. M. Zebarjad, S. H. NoieBaghban, A. Youssef, M. S. Ekrami-Kakhki   +4 more
doaj