Results 81 to 90 of about 5,747,403 (195)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Lattice thermal conductivity of a silicon nanowire under surface stress

, 2011
The effects of surface stress on the lattice thermal conductivity are investigated for a silicon nanowire. A phonon dispersion relation is derived based on a continuum approach for a nanowire under surface stress.
Puri, Ishwar K., Liangruksa, Monrudee, Ishwar K. Puri, Monrudee Liangruksa   +3 more
core   +1 more source

Chalcogen passivation: an in-situ method to manipulate the morphology and electrical property of GaAs nanowires

Scientific Reports, 2018
Recently, owing to the large surface-area-to-volume ratio of nanowires (NWs), manipulation of their surface states becomes technologically important and being investigated for various applications.
Zai-xing Yang, Yanxue Yin, Jiamin Sun, Luozhen Bian, Ning Han, Ziyao Zhou, Lei Shu, Fengyun Wang, Yunfa Chen, Aimin Song, Johnny C. Ho   +10 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Thermal conductivity measurement of liquids in a microfluidic device [PDF]

, 2010
A new microfluidic-based approach to measuring liquid thermal conductivity is developed to address the requirement in many practical applications for measurements using small (microlitre) sample size and integration into a compact device.
M. R. Bown, Newton, M.I., Allen, R. W.K., Ge, Rile, Ge, R., Kuvshinov, Dmitriy, MacInnes, J. M., Hardacre, C., Hardacre, C.; id_orcid, Doy, N., McHale, G., Allen, R. W K, Newton, Michael, Bown, Mark, Aldous, L., Allen, R.W.K., Newton, M. I., R. Ge, Hardacre, Christopher, N. Doy, D. Kuvshinov, Allen, Ray, Doy, Nicola, Kuvshinov, D., Bown, M.R., L. Aldous, MacInnes, Jordan, R. W. K. Allen, Allen, R. W. K., McHale, Glen, J. M. MacInnes, G. McHale, Aldous, Leigh, C. Hardacre, MacInnes, J.M., M. I. Newton, Bown, M. R., Allen, RWK, Newton, MI, Bown, MR, Hardacre, C, McHale, G, MacInnes, JM, Doy, N, Ge, R, Aldous, L, Kuvshinov, D   +46 more
core   +1 more source

Characterization Method for the Conductive Response of Shale Based on Multi-Dimensional Fractal Theory

Fractal and Fractional
Resistivity is a key parameter in shale reservoir characterization. Diverse micro-pore types and complex conduction mechanisms in shale result in poor accuracy when applying existed conductivity models. Establishing a high-precision conductivity response
Weibiao Xie, Qiuli Yin, Xueping Dai, Jianbin Zhao, Jingbo Zeng, Pan Zhang   +5 more
doaj   +1 more source

Field investigation of efficient thermal conductivity of snow cover on Spitsbergen

Лëд и снег, 2015
This paper presents results of field investigations of coefficient of efficient thermal conductivity of snow with different structures and densities. Observations were performed in spring of 2013 in the vicinity of meteorological station Barentsburg. The
N. I. Osokin, A. V. Sosnovsky
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Surface Graphitized Mesoporous Carbon Surpasses the Conductivity–Porosity Trade‐Off

Advanced Science
In carbon engineering, a longstanding trade‐off persists: chemical activation increases surface area but sacrifices conductivity, whereas graphitization enhances conductivity at the expense of porosity.
Juntian Fan, Yating Yuan, Tao Wang, Huimin Luo, Fan Wang, Qingju Wang, Shannon M. Mahurin, Bishnu P. Thapaliya, Lilin He, Jue Liu, Nikolaos Samartzis, Zhenzhen Yang, Sheng Dai   +12 more
doaj   +1 more source