Results 81 to 90 of about 5,064,148 (288)

Deducing the internal interfaces of twisted multilayer graphene via moiré-regulated surface conductivity. [PDF]

Natl Sci Rev, 2023
Wang H, Wang S, Zhang S, Zhu M, Ouyang W, Li Q.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Studies of the Adsorption of SO, H and O on a CrO Surface by an Electrical Conductivity Technique

Adsorption Science & Technology, 1999
Electrical conductivity measurements have been used to detect extremely small changes in the oxygen content of oxide semiconductors in contact with reducing or oxidizing gases. In continuation of previous studies, the oxygen loss of chromium oxide in H 2
Mahmoud M. Khader, Mahmoud M. Saleh, Ahmad M. Mohammad   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Anisotropic thermal conductivity and permeability of compacted expanded natural graphite [PDF]

, 2010
The anisotropic thermal conductivities and permeabilities are investigated for discs and plates of compacted expanded natural graphite. The measuring directions of heat conductivity and permeability are both parallel and perpendicular to the pressing ...
Tamainot-Telto, Zacharie, Wang, L. W., Wang, R. Z., Critoph, Robert E., Metcalf, Steven J.   +4 more
core   +1 more source

Chalcogen passivation: an in-situ method to manipulate the morphology and electrical property of GaAs nanowires

Scientific Reports, 2018
Recently, owing to the large surface-area-to-volume ratio of nanowires (NWs), manipulation of their surface states becomes technologically important and being investigated for various applications.
Zai-xing Yang, Yanxue Yin, Jiamin Sun, Luozhen Bian, Ning Han, Ziyao Zhou, Lei Shu, Fengyun Wang, Yunfa Chen, Aimin Song, Johnny C. Ho   +10 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Absence of intrinsic electric conductivity in single dsDNA molecules [PDF]

, 2004
Kleine H, Wilke R, Pelargus C, et al. Absence of intrinsic electric conductivity in single dsDNA molecules. Journal of Biotechnology. 2004;112(1-2):91-95.The intrinsic dc conductivity of long, individual lambda phage dsDNA molecules has been investigated
Rott, Karsten, Pelargus, Christoph, Ros, Robert, Wilke, Ralf, Kleine, Hermann, Pühler, Alfred ; https://orcid.org/, Reiss, Günter, Anselmetti, Dario ; https://orcid.org/   +7 more
core   +1 more source