Results 71 to 80 of about 5,747,403 (195)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Open-Cell Metal Foams for Use in Dehumidifying Heat Exchangers [PDF]
, 2012 Metal foams with an open-cell structure have physical and mechanical properties suggesting they might have advantages over conventional fin materials for use in air-cooling heat exchangers.
Jacobi, Anthony M. +3 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Japan Architectural Review, 2018 In this study, a method for predicting the unexposed surface temperature of a wall is proposed based on the concept of “inclusive thermal conductivity,” which considers the heat and mass transfer of materials containing moisture.
Kimie Yoshitani +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
MATHEMATICAL FORMULATION OF SURFACE CONDUCTIVITY FOR GRAPHENE MATERIAL [PDF]
Journal of Engineering Science and Technology, 2017 The graphene material is currently being used in the design of nano components and devices for wireless applications in terahertz (THz) regime as it possesses a number of desirable electromagnetic and mechanical properties that assist in providing ...
BALA R., MARWAHA A., MARWAHA S.
doaj
Studies of the Adsorption of SO, H and O on a CrO Surface by an Electrical Conductivity Technique
Adsorption Science & Technology, 1999 Electrical conductivity measurements have been used to detect extremely small changes in the oxygen content of oxide semiconductors in contact with reducing or oxidizing gases. In continuation of previous studies, the oxygen loss of chromium oxide in H 2
Mahmoud M. Khader +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source