Results 91 to 100 of about 363,241 (312)
Nihon Kikai Gakkai ronbunshuFatigue failure involves fatigue crack initiation and propagation processes. In bulk metals, the fatigue crack initiation process is strongly affected by a dissimilar surface layer, while the fatigue crack propagation process is less affected.
Toshiyuki KONDO +3 more
doaj +1 more source
Prediction of fatigue crack-growth patterns and lives in three-dimensional cracked bodies [PDF]
Fatigue crack growth patterns and lives for surface cracks, surface cracks at holes, and corner cracks at holes in three dimensional bodies were predicted using linear-elastic fracture mechanics concepts that were modified to account for crack-closure ...
Newman, J. C., Jr., Raju, I. S.
core +1 more source
Crack dynamics and crack surfaces in elastic beam lattices
Physical Review E, 1998 The dynamics of propagating cracks is analyzed in elastic two-dimensional lattices of beams. At early times, inertia effects and static stress enhancement combine so that the crack-tip velocity is found to behave as ${t}^{1/7}.$ At late times a minimal crack-tip model reproduces the numerical simulation results. With no disorder and for fast loading, a
Åström, J., Alava, M., Timonen, J.
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fatigue crack growth in a particulate TiB2 reinforced powder metallurgy iron-based composite
, 2003 Fatigue crack growth behavior has been examined in a particulate titanium diboride (TiB2)–reinforced iron-based composite that had been produced via a mechanical alloying process.
Sinclair, I., Yang, N.
core +1 more source
Fatigue crack growth behavior for 3D inclined surface crack
IOP Conference Series: Materials Science and Engineering, 2011 In the present study, the fatigue life and surface crack extension direction in a cylindrical elastic bar with an inclined surface crack were experimentally investigated. The effects of loading type, stress ratio and crack inclination angle on the crack growth behavior were also determined.
F P Yang +3 more
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Fatigue Life Prediction of Pipe with Cracks on External Surface
Shiyou jixie, 2020 To effectively predict the fatigue crack propagation life of pipe with external surface crack, based on the extended finite element method, the stress intensity factor of the crack on the external surface of the pipe was calculated at different pipe ...
Zhao Yizhao +4 more
doaj
Deformation mechanics of deep surface flaw cracks [PDF]
A combined analytical and experimental program was conducted to determine the deformation characteristics of deep surface cracks in Mode I loading. An approximate plane finite element analysis was performed to make a parameter study on the influence of ...
Beissner, R. E. +2 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source