Results 61 to 70 of about 4,863,941 (314)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Combining 15 years of microwave SST and along-track SSH to estimate ocean surface currents [PDF]
, 2016 International audienceOcean surface current is one of the main oceanographic variables. To estimate and track these currents, we use satellite measurements of Sea Surface Height (SSH), but these data are sparse in space and time, as they are collected ...
Tandeo, Pierre +6 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A numerical investigation of constant-volume non-Boussinesq density currents [PDF]
, 2010 The time-dependent behaviour of non-Boussinesq high-Reynolds-number density currents of density ρc, released from a lock of height h₀ and length x₀ into a ambient of height H and density ρₐ, is considered. We use two dimensional Navier-Stokes simulations
Ungarish, Marius +2 more
core
Surface currents of the Ibiza Channel (October 2014)
, 2021 In this document we describe a new application of DIVAnd (Data-Interpolating Variational Analysis, in n-dimensions) for high-frequency (HF) radar currents.
Beckers, Jean-marie +5 more
core +1 more source
Numerical simulations of the spread of floating passive tracer released at the Old Harry prospect
Environmental Research Letters, 2014 The Gulf of St Lawrence is under immediate pressure for oil and gas exploration, particularly at the Old Harry prospect. A synthesis of the regulatory process that has taken place over the last few years indicates that important societal decisions soon ...
Daniel Bourgault +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
World Surface Currents from Ship's Drift Observations [PDF]
, 2015 Over 4 million observations of ship’s drift are on file at the U.S. National Oceanographic Data Centre, in Washington, D.C., representing a vast amount of information on ocean surface currents.
Duncan, C. P., Schladow, S. G.
core
Remote SensingThe performance of a high-frequency (HF) radar network situated within the Pearl River Estuary from 17 July to 13 August 2022 is described via a comparison with seven acoustic Doppler current profilers (ADCPs).
Langfeng Zhu +4 more
doaj +1 more source