Results 81 to 90 of about 654,094 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hindcasting and Forecasting of Surface Flow Fields through Assimilating High Frequency Remotely Sensing Radar Data

Remote Sensing, 2017
In order to improve the forecasting ability of numerical models, a sequential data assimilation scheme, nudging, was applied to blend remotely sensing high-frequency (HF) radar surface currents with results from a three-dimensional numerical, EFDC ...
Lei Ren, Michael Hartnett
doaj   +1 more source

Analytical and experimental studies of thermionically emitting electrodes in contact with dense, seeded plasmas [PDF]

, 1970
Interactions are considered between a moving, alkali-metal seeded, dense plasma and a metallic electrode whose surface properties are influenced by the absorption of seed particles. The plasma behavior is governed by a set of differential equations,
Koester, John K., Sajben, Miklos, Zukoski, Edward E.   +2 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Tracking Pelagia noctiluca scyphomedusae by combining modeling and stable isotope approaches

Frontiers in Marine Science
True jellyfish (Cnidaria, Scyphozoa) often appear in large aggregations along the coasts, where they interfere with human activities (tourism, fisheries, power plants).
Isabella D’Ambra, Isabella D’Ambra, Simona Saviano, Maria Assunta Ambrosio, Vincenzo Botte, Daniele Iudicone, Maria Grazia Mazzocchi, Louise Merquiol, Louise Merquiol, Louise Merquiol, Daniela Cianelli   +10 more
doaj   +1 more source

On the Optimal Design of Doppler Scatterometers

Remote Sensing, 2018
Pencil-beam Doppler scatterometers are a promising remote sensing tool for measuring ocean vector winds and currents from space. While several point designs exist in the literature, these designs have been constrained by the hardware they inherited, and ...
Ernesto Rodriguez
doaj   +1 more source

Persistent currents in carbon nanotubes

, 2002
Persistent currents driven by a static magnetic flux parallel to the carbon nanotube axis are investigated. Owing to the hexagonal symmetry of graphene the Fermi contour expected for a 2D-lattice reduces to two points. However the electron or hole doping
Ando, Byszewski, Cheung, Cheung, E Zipper, Fujiwara, Kim, Krüger, Lee, Lin, Lu, M Margańska, M Szopa, Marganska, Roche, Roche, Saito, Schönenberger, Stebelski, Wohlleben   +19 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Effect of Wind Forcing on Modeling Coastal Circulation at a Marine Renewable Test Site

Energies, 2017
The hydrodynamic circulation in estuaries is primarily driven by tides, river inflows and surface winds. While tidal and river data can be quite easily obtained for input to hydrodynamic models, sourcing accurate surface wind data is problematic ...
Lei Ren, Diarmuid Nagle, Michael Hartnett, Stephen Nash   +3 more
doaj   +1 more source