Results 91 to 100 of about 50,696 (309)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effect of Wood Surface Finish on Wood Species Classification Using Spectral Reflectance

BioResources
Wood species can be classified by spectral reflectance. It is unclear whether finish coated on the wood surface affects the accuracy of wood species classification.
Cheng-Kun Wang, Peng Zhao, Jia-Le Yang
doaj   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Substrate surface finish effects on scratch resistance and failure mechanisms of TiN-coated hardmetals

, 2015
In this study, the influence of substrate surface finish on scratch resistance and associated failure mechanisms is investigated in the case of a TiN-coated hardmetal.
Johansson-Jöesaar, Mats P.,, Odén, Magnus,, Roa, J. J.,, Llanes, L.,, Esteve, J.,, Yang, J.,   +5 more
core   +1 more source

Parametric Effect on Surface Finish of Three-Dimensional Printed Object

International Journal of Engineering Materials and Manufacture, 2018
The ability to use different parameters and finishing techniques in fused deposition modelling (FDM) depends largely on part geometries, materials, printing processes like Z-resolution and post processing to some extent.
Muhammad Hasibul Hasan, Shugata Ahmed, Ron Voldman, Mirt Mehany   +3 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Comparing Bio-Ester and Mineral-Oil Emulsions on Tool Wear and Surface Integrity in Finish Turning a Ni-Based Superalloy [PDF]

Metalworking Fluid (MWF), also known in the industry as a coolant, provides essential lubrication and cooling to tools and workpieces, reducing friction and tool wear to enhance productivity and maintain the surface integrity of the part produced.
Paul Wood, Fathi Boud, Andrew Mantle, Miguélez Garrido, María Henar, Carter, Wayne, Pawlik, Marzena, Wayne Carter, Syed Hossain, Mantle, Andrew, Urvashi Gunputh, Hossain, Syed, José Díaz-Álvarez, Lu, Yiling, Marzena Pawlik, María Henar Miguélez, Díaz Álvarez, José, Yiling Lu, Boud, Fathi, Gunputh, Urvashi Fowdar, Wood, Paul   +19 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source