Results 101 to 110 of about 50,696 (309)

Surface Finish after Laser Metal Deposition

, 2013
Laser metal deposition (LMD) is an additive manufacturing technology for the fabrication of metal parts through layerwise deposition and laser induced melting of metal powder. The poor surface finish presents a major limitation in LMD. This study focuses
Rombouts, M., Hendrix, W., Maes, G., Motmans, F., Delarbre, E.   +4 more
core   +1 more source

Influence of conductive powders on surface characteristics in EDM: an experimental study using desirability optimization

Journal of the Mechanical Behavior of Materials
The advancement of modern engineering materials with superior mechanical properties such as hardness, toughness, and brittleness presents significant challenges to conventional machining techniques, often leading to tool failure and poor surface finish ...
Huu Phan Nguyen, Ganachari Vaibhav Sidraya, Shirguppikar Shailesh, Gavali Pankaj Balasaheb, Lakshmanan Selvarajan, Van Dong Pham, Muthuramalingam Thangaraj, Le Quang Dung   +7 more
doaj   +1 more source

Retained Austenite Control for the Soft Machining of High-Hardness Tool Steels

Metals, 2018
Most high-hardness tool steels comprising forming dies require expensive finish machining operations to compensate for the dimensional distortion and surface oxidation caused by the die heat treatment.
Maider Muro, Garikoitz Artola, Josu Leunda, Carlos Soriano, Carlos Angulo   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Importance of surface topography on pulsed laser-induced damage threshold of Sapphire crystals

Scientific Reports, 2017
We measure the laser-induced damage threshold (LIDT) fluence under single shot at the surface of Sapphire samples prepared following the standards of two methods yielding to different surface finish and used in optical and laser industry.
Benoît Bussière, Nicolas Sanner, Marc Sentis, Olivier Utéza   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Corrective Abrasive Polishing Processes for Freeform Surface [PDF]

, 2009
Traditionally, abrasive finishing process only focused on producing excellent surface finish on regular form shapes. Ever increasing demands in freeform features in aerospace, energy and medicine applications require abrasive finishing technology not ...
Chen, Xun
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Analyzing the Relationship between the Chemical Composition and the Surface Finish of Alnico Alloys in EDM. [PDF]

Materials (Basel), 2023
Młynarczyk P, Bańkowski D, Szwed B.
europepmc   +1 more source