Results 121 to 130 of about 50,696 (309)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Effects of Process Parameters on Surface Finish in Cylindrical Grinding

open access: yes, 2011
Cylindrical grinding is an efficient and useful method of achieving good dimensional accuracy and fine finish. Very often one of the main objectives of grinding process is to obtain very good surface finish.
Asish Bandyopadhyay   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Demonstrator for Optical Surface Finish Measurements

open access: yes, 2009
Final report and prototype photo for Project 19 of ME450, Fall 2009 semester.The goal of this project is to build a proof-of-concept demonstrator that can measure surface finish properties using a method of light reflectivity.Yoram Koren (Mechanical ...
Antonini, Kyle   +3 more
core  

3.16 Hard Coatings on Cutting Tools and Surface Finish

open access: yes, 2017
Performance of a machined part surface depends mostly on surface finish obtained on that part. Surface roughness, residual stress, microstructure, and hardness are some characteristics of the machined surface to be taken into account.
P. Panjan   +5 more
core   +1 more source

A Study of Evaluation of Finish Line of Die in Fixed Prosthodontic Laboratory

open access: yesUpdate Dental College Journal
Background: The purpose of a fixed prosthodontic treatment may vary from the restoration of a single tooth to the complete rehabilitation of full occlusion.
Md Alamgir Kabir   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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