Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Al-Khawarizmi Engineering Journal, 2019 The surface finish of the machining part is the mostly important characteristics of products quality and its indispensable customers’ requirement. Taguchi robust parameters designs for optimizing for surface finish in turning of 7025 AL-Alloy using ...
Safaa K. Ghazi +3 more
doaj
Tin Whiskers' Behavior under Stress Load and the Mitigation Method for Immersion Tin Surface Finish. [PDF]
Materials (Basel), 2021 Fadil NA +6 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Discover MaterialsThis study investigates surface roughness evolution during abrasive flow machining (AFM) of four commonly used engineering materials mild steel, brass, copper, and aluminium under a fixed experimental window comprising a single abrasive size (65 μm SiC),
Yared Seifu Woldeyohannis +3 more
doaj +1 more source
Effect of Microstructure and Dislocation Density on Material Removal and Surface Finish of Laser Powder Bed Fusion 316L Stainless Steel Subject to a Self-Terminating Etching Process. [PDF]
3D Print Addit Manuf, 2023 Prochaska S, Walker M, Hildreth O.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Effect of Some Cutting Parameters on Surface Finish of Bright Mild Steel
Journal of Applied Sciences and Environmental ManagementThe objective of this paper was to evaluate the effect of some cutting parameters on surface finish of bright mild steel (BMS). Samples were cut into the required piece with dimension 50mm x 200mm and the turning operation done using a tungsten carbide ...
E. Obojoh, T. I. Francis-Akilaki
doaj
Material removal investigation in bonnet polishing of CoCr alloy [PDF]
, 2012 The manufacture of orthopaedic joint bearings surfaces requires exceptionally high levels of control of not only the surface finish but also the surface form.
Blunt, Liam, Jiang, Xiang, Zeng, S.
core
Effect of Ni(P) Layer Thickness on Interface Reaction and Reliability of Ultrathin ENEPIG Surface Finish. [PDF]
Materials (Basel), 2021 Chi P +6 more
europepmc +1 more source