Results 91 to 100 of about 198,686 (307)

Effect of machining-induced harden layer on wear resistance of Type316L austenitic stainless steel

Nihon Kikai Gakkai ronbunshu
In order to clarify the effect of surface hardening layers induced during machining processes such as cutting and grinding on the wear resistance of austenitic stainless steel SUS316L, a surface hardening layer was intentionally induced on SUS316L ...
Naoaki NAGAISHI, Keiji HOAKI, Kazunori KODA   +2 more
doaj   +1 more source

Influence of Shot Peening on AlSi10Mg Parts Fabricated by Additive Manufacturing

Journal of Manufacturing and Materials Processing, 2018
The additive manufacturing (AM) of aluminum alloys promises to considerably enhance the performance of lightweight critical parts in various industrial applications.
Ahmed H. Maamoun, Mohamed A. Elbestawi, Stephen C. Veldhuis   +2 more
doaj   +1 more source

A novel indicator for kinematic hardening effect quantification in deep drawing simulation [PDF]

, 2019
Deep drawing simulation techniques reduce tool design costs and improve tool performance and reliability. In terms of strain hardening, mixed models capturing the kinematic effect are sometimes more accurate than isotropic models.
Brosius, Alexander, Küsters, Niklas, Lafarge, Rémi   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The effect of elevated temperature and tensile force loading on the relaxation of residual stresses in surface-hardened elements of the rod structure under creep conditions

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2019
A mathematical model for the relaxation of residual stresses in surface-hardened cylindrical elements of statically indefinable rod systems under creep conditions with elevated temperature and tensile force loading was developed.
Vladimir Pavlovich Radchenko, Ekaterina E Derevyanka   +1 more
doaj   +1 more source

Surface Hardening of Tungsten Heavy Alloys

Scripta Materialia, 1997
Tungsten-based heavy alloys are produced by sintering from elemental W, Ni, Fe and Cu powder mixtures, where the tungsten content is in the range 80--98 weight%. The alloys, however, show relatively poor surface properties such as wear and corrosion resistance.
Eroglu, S, Ekren, H, Baykara, T
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Calibration of the hardening soil model in excalibre

Acta Polytechnica CTU Proceedings
The hardening soil model is one of the most commonly used constitutive models in engineering practice. This model is based on multi-surface plasticity and combines the well-known Mohr-Coulomb failure criterion, a hardening shear surface and a cap yield ...
Do Chinh Phuong, Tomáš Kadlíček, David Mašín, Jan Najser   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source