Results 81 to 90 of about 198,686 (307)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Effect of laser surface treatment on the some of mechanical properties of AISI 4130 steel [PDF]

Engineering and Technology Journal, 2017
In this work the surface of an alloy of AISI 4130 steel is hardened by using CW Nd:YAG laser and then study the effect of laser surface hardening on mechanical properties such as yield strength (σy), ultimate tensile strength (σu.T.S), plasticity ...
J.M. Taha
doaj   +1 more source

Dual weighted residual method for laser surface hardening of steel problem [PDF]

, 2011
. The main focus of this article is on the development of Adaptive Finite Element Method (AFEM) for the optimal control problem of laser surface hardening of steel governed by a dynamical system consisting of a semi-linear parabolic equation and an ...
Amiya K, Gupta Nupur, Nataraj Neela, Pani Amiya K   +3 more
core   +1 more source

Surface microhardening studies on steels after high feed milling [PDF]

, 2018
The paper deals with the impact of high-speed machining production methods on the integrity of component surfaces. One has to point out that cutting conditions during machining have a significant impact on the final properties of surface and subsurface ...
Petrů, Jana, Zlámal, Tomáš, Čep, Robert, Špalek, František   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Nonvolume Preserving Plasticity Theory with Applications to Powder Metallurgy [PDF]

, 1983
A plasticity theory has been developed to predict the mechanical response of powder metals during hot isostatic pressing. The theory parameters were obtained through an experimental program consisting of hydrostatic pressure tests, uniaxial compression ...
Cassenti, B. N.
core   +1 more source

Simulation of Flow of Mixtures Through Anisotropic Porous Media using a Lattice Boltzmann Model [PDF]

, 2009
We propose a description for transient penetration simulations of miscible and immiscible fluid mixtures into anisotropic porous media, using the lattice Boltzmann (LB) method. Our model incorporates hydrodynamic flow, diffusion, surface tension, and the
A. Hiorth, A. Morais, A.K. Gunstensen, B. Chopard, C.L. Tien, C.T. Hsu, D. Grunau, D.J. Korteweg, D.M. Anderson, E.G. Flekkoy, F. Higuera, F. K. Wittel, F. Kamke, F. Wittel, G.R. McNamara, H. J. Herrmann, J. Chin, J. Tolke, M. Latva-Kokko, M. Mendoza, M. Mendoza, N. Mouchot, O. Bouriaud, P. Bathnagar, P. Nithiarasu, P. Perre, S. Chen, S. Succi, S. Succi, T. Reis, T. Reis, U. Frisch, X. Shan, Z. Guo, Z. Guo   +34 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source