Results 111 to 120 of about 198,686 (307)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Laser Surface Hardening of 51CrV4 Steel
The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2005 The work presents the surface changes in microstructure and properties by quenching the 51CrV4 steel from liquid and solid phase, using a CO2 continue laser wave with 900W power.
Sanda Maria LEVCOVICI +1 more
doaj
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Comparison of Surface Hardening Processes Applied to AISI 5140 Steel withSide Load Test
International Journal of Automotive Science and TechnologyAISI 5140 Tempered steel is generally preferred in the joints of vehicles. This steel is a material with high toughness. Its usage areas are quite wide.
Talha İkbal Çığır +3 more
doaj +1 more source
Evolution of nonlocal damage in steel under cyclic straining [PDF]
, 2013 For high dynamic excitation, e.g. by earthquakes, the vibrations of steel structures lead to inelastic material behavior. Hystereses, developing under cyclic loading, are responsible for the dissipation of energy.
Dinkler, Dieter +2 more
core
Analysis of stevia extract and compare active functional group with other artificial sweetener; aspartame and sucralose [PDF]
, 2020 Sugar is very important for everyday use especially for humans as food and drinks as additives. Among all types of sweeteners; sucrose, aspartame and sucralose are widely used in foods and beverage industries.
Ismail, Siti Nur Bahirah +3 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Decarburization in Laser Surface Hardening of AISI 420 Martensitic Stainless Steel. [PDF]
Materials (Basel), 2023 Aprilia A, Maharjan N, Zhou W.
europepmc +1 more source