Results 111 to 120 of about 108,558 (304)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Ice Lines, Planetesimal Composition and Solid Surface Density in the Solar Nebula

, 2008
To date, there is no core accretion simulation that can successfully account for the formation of Uranus or Neptune within the observed 2-3 Myr lifetimes of protoplanetary disks.
A'Hearn, Abe, Aikawa, Aikawa, Alexander, Alibert, Allen, Anders, Baines, Balbus, Barucci, Barzel, Bell, Boss, Caselli, Cazaux, Charles A. Beichman, Charnley, Chiang, Chiang, Ciesla, Ciesla, Collings, D'Alessio, Dodson-Robinson, Dullemond, Ferguson, Flasar, Fraser, Gail, Garrod, Grundy, Haisch, Hallenbeck, Hasegawa, Hasegawa, Hawley, Hawley, Hayashi, Helling, Herbst, Hersant, Hersant, Hersant, Hornekaer, Hubbard, Hubickyj, Hussmann, Ilgner, Jessberger, Karen Willacy, Katz, Keller, Kippenhahn, Kretke, Lodders, Lodders, Lodders, Lopes, Lynden-Bell, Lyra, Mihalas, Millar, Milsom, Neal J. Turner, Owen, Owen, Owen, Peter Bodenheimer, Pollack, Press, Pringle, Reyes-Ruiz, Rivkin, Ruden, Ruden, Ruffle, Sandford, Sarah E. Dodson-Robinson, Semenov, Shakura, Spohn, Stepinski, Tielens, Tielens, Tsiganis, Turner, Umebayashi, Umebayashi, van Boekel, Weidenschilling, Willacy, Willacy, Womack, Woods, Öberg   +95 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Chemical Evolution of Isotopically Labeled Carbon Dioxide (13CO2) Ice Exposed to Ionizing Radiation and Implications for Trans-Neptunian Objects

The Astrophysical Journal
We present results on the radiation chemistry of isotopically labeled carbon dioxide ( ^13 CO _2 ) ices induced by energetic electrons at 40 and 10 K to simulate the chemical evolution of carbon dioxide on trans-Neptunian objects exposed to galactic ...
Chaojiang Zhang, Leslie A. Young, Ralf I. Kaiser   +2 more
doaj   +1 more source

New insights into gully formation on Mars: Constraints from composition as seen by MRO/CRISM

Geophysical Research Letters, 2016
Over 100 Martian gully sites were analyzed using orbital data collected by the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) and High Resolution Imaging Science Experiment on the Mars Reconnaissance Orbiter (MRO).
J. I. Núñez, O. S. Barnouin, S. L. Murchie, F. P. Seelos, J. A. McGovern, K. D. Seelos, D. L. Buczkowski   +6 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The Fate of Simple Organics on Titan's Surface: A Theoretical Perspective

Geophysical Research Letters
Atmospheric photochemistry on Titan continuously transforms methane and nitrogen gases into various organic compounds. This study explores the fate of these molecules when they land on Titan's surface.
Xinting Yu, Yue Yu, Julia Garver, Xi Zhang, Patricia McGuiggan   +4 more
doaj   +1 more source

PICES Press, Vol. 7, No. 2, July 1999 [PDF]

, 1999
Improving PICES CO2 measurement quality The status of the Bering Sea: July - December 1998 The state of the eastern North Pacific since October 1998 The state of the western North Pacific in the second half of 1998 Paul Henry LeBlond Report on ...

core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Infrared Spectra of Organic and Salt-bearing Ices under Titan Conditions: Constraints on Detection of Ocean Materials

The Planetary Science Journal
Titan, with its organic-rich atmosphere and global subsurface ocean, has long been considered a prime candidate to potentially host life beyond Earth.
Paul V. Johnson, Robert Hodyss, Michael J. Malaska   +2 more
doaj   +1 more source