Results 61 to 70 of about 108,558 (304)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Inderwater noise characteristics of TINRO-Center’s reseach vessels

Известия ТИНРО, 2014
Underwater noise radiated by two medium-tonnage research vessels of Pacific Fish. Res. Center (TINRO) belonged to the same project «Atlantic-833» (RV TINRO and Professor Kaganovsky) is measured by a calibrated hydrophone system.
Michail Yu. Kuznetsov, Vasiliy I. Shevtsov, Vladimir I. Poljanichko   +2 more
doaj   +1 more source

Radiolysis of ammonia-containing ices by energetic, heavy and highly charged ions inside dense astrophysical environments [PDF]

, 2009
Deeply inside dense molecular clouds and protostellar disks, the interstellar ices are protected from stellar energetic UV photons. However, X-rays and energetic cosmic rays can penetrate inside these regions triggering chemical reactions, molecular ...
Balanzat, E., Boduch, P., da Silveira, E. F., Domaracka, A., Duarte, E. Seperuelo, Pilling, S., Rothard, H.   +6 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The ancient heritage of water ice in the solar system [PDF]

, 2014
Identifying the source of Earth's water is central to understanding the origins of life-fostering environments and to assessing the prevalence of such environments in space.
Alexander, Conel M. O'D., Bergin, Edwin A., Cleeves, L. Ilsedore, Du, Fujun, Graninger, Dawn, Harries, Tim J., Öberg, Karin I.   +6 more
core   +2 more sources

Affordable Biogenic Anti‐Icing Surfaces

Advanced Materials Interfaces
AbstractIn this study, the development of low‐cost biogenic anti‐icing coatings that heat up upon irradiation is reported. Charcoal from coconut shells is milled into various particle sizes (Ranging from <90 µm to >600 µm) and immobilize onto glass using epoxy adhesives is reported.
Yiqing Xue, Philip Verdross, Robert T. Woodward, Wenyan Liang, Alexander Bismarck   +4 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A fisheries acoustic multi-frequency indicator to inform on large scale spatial patterns of aquatic pelagic ecosystems [PDF]

, 2013
Fisheries acoustic instruments provide information on four major groups in aquatic ecosystems: fish with and without swim bladder (tertiary and quaternary consumers), fluidlike zooplankton (secondary consumers) and small gas bearing organisms such as ...
Bergen, Laurent, Trenkel, Verena
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Optical Spectroscopy of the Uranian Moons from Equinox to Northern Summer

The Planetary Science Journal
We present an analysis of ground-based visible and near-infrared wavelength (VIS, ∼0.4–0.9 μ m) reflectance spectra of the four largest Uranian satellites, utilizing observations with multiple telescopes, collected near Uranian equinox and in northern ...
Riley A. DeColibus, Richard J. Cartwright, William M. Grundy, Bonnie J. Buratti, Michael D. Hicks, Ishan Mishra   +5 more
doaj   +1 more source