Results 91 to 100 of about 1,188,516 (315)

Research and development of metals for medical devices based on clinical needs

open access: yesScience and Technology of Advanced Materials, 2012
The current research and development of metallic materials used for medicine and dentistry is reviewed. First, the general properties required of metals used in medical devices are summarized, followed by the needs for the development of α + β type Ti ...
Takao Hanawa
doaj   +1 more source

Wear Behaviour of UHMWPE Against DC‐Pulsed Plasma Nitrided and Duplex Treated AISI 316L Used in Hip Joint Replacements

open access: yes, 2009
Wear behaviour of the artificial joint replacements plays a critical role in implant failure. The UHMWPE-AISI 316L tribological system, widely used on joint prostheses, was studied.
Parodi, Belén   +11 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

On Riemann method for solving a mixed problem

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2007
The formula for solution of a problem for an equation with the higher partial derivative of the general type is constructed using Riemann method. In this problem the solution is found in the characteristic parallelepiped with separated by the non ...
A. N. Mironov
doaj   +1 more source

Key varieties for surfaces of general type [PDF]

open access: yes, 2008
The study of canonical models of surfaces of general type is a subject which has been of interest for many years, since the time of Enriques. The major question is: given particular values of pg and K2 can one construct the moduli space of regular ...
Coughlan, Stephen Thomas
core  

Acute Gastroenteritis and Campylobacteriosis in Swiss primary care: the viewpoint of general practitioners [PDF]

open access: yes, 2016
Acute gastroenteritis (AG) is frequently caused by infectious intestinal diseases (IID) including food- and waterborne pathogens of public health importance. Among these pathogens, Campylobacter spp. plays a major role.
Zeller, Andreas   +9 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

THE INFLUENCES OF NATURAL GAS IMPURITIES TO THE SURFACE TENSION OF BLENDED PIPERAZINE-N-METHYLDIETHANOLAMINE (MDEA) SOLUTION [PDF]

open access: yes, 2008
This study focuses on the effect of impurities in the natural gas stream on the characteristic of surface tension in the blended piperazine and MDEA solution.
Ismail, Ahmad Fauzi, Ratman, Iwan
core  

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