Results 81 to 90 of about 1,188,516 (315)
Limits of nodal surfaces and applications
Forum of Mathematics, SigmaLet $\mathcal {X}\to \mathbb {D}$ be a flat family of projective complex 3-folds over a disc $\mathbb {D}$ with smooth total space $\mathcal {X}$ and smooth general fibre $\mathcal {X}_t,$ and whose special fiber $\mathcal
Ciro Ciliberto, Concettina Galati
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Heating mechanism of self-interaction of surface polaritons at n-type semiconductor-metal interface
, 1993 The influence of electron heating in the high-frequency surface polariton (SP) field on the dispersion properties of the SPs considered is investigated.
Ostrikov, K., Smolin, A.V.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
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On the class of projective surfaces of general type
Hokkaido Mathematical Journal, 2017 Let $S$ be a smooth complex projective surface of general type, $H$ be a very ample divisor on $S$ and $m(S,H)$ be the class of $(S,H)$. In this paper, we study a lower bound for $m(S,H)-3H^2$ and we improve an inequality obtained by Lanteri. We also study $(S,H)$ with each value of $m(S,H)-3H^2$ and exhibit some examples.
FUKUMA, Yoshiaki, ITO, Kazuhisa
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
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Frontiers in Plant ScienceThioredoxins are ubiquitous disulfide reductases folded as an α/β domain of 100-120 amino acid residues. Functional redox site is composed of a pair of cysteines in a canonical WCGPC pentapeptide exposed at the surface of thioredoxins, that reduces ...
Stéphane D. Lemaire +5 more
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Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains [PDF]
, 2014 The Type VII protein secretion system, found in Gram-positive bacteria, secretes small proteins, containing a conserved W-x-G amino acid sequence motif, to the growth medium.
Chalmers, James +16 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
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