Results 161 to 170 of about 22,416,474 (360)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Surface Decorations on Mixed Ionic and Electronic Conductors: Effects on Surface Potential, Defects, and the Oxygen Exchange Kinetics. [PDF]

ACS Appl Mater Interfaces, 2023
Riedl C, Siebenhofer M, Nenning A, Wilson GE, Kilner J, Rameshan C, Limbeck A, Opitz AK, Kubicek M, Fleig J.   +9 more
europepmc   +1 more source

Tunable Schottky barrier height and surface potential by using hydrogen ions

, 2014
In this research work, hydrogen ion can be used for Schottky barrier height and surface potential tuning with specific power. The current output of Ohmic and Schottky contacted device would be enhanced from 8.25 μA to 171 μA and 2.84 pA to 1.3 μA ...
Yeh, P. H., Hsu, J. K.; Lin, T. Y.; Lai, C. Y.; Chien, T. C.; Song, J. H.; Yeh, P. H.   +1 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploring the Surface Potential of Recycled Polyethylene Terephthalate Composite Supports on the Collagen Contamination Level. [PDF]

Polymers (Basel), 2023
Epure EL, Cojocaru FD, Aradoaei M, Ciobanu RC, Dodi G.   +4 more
europepmc   +1 more source

Surface-modified gatifloxacin nanoparticles with potential for treating central nervous system tuberculosis

, 2017
Patricia Marcianes,1 Sofia Negro,1,2 Luis García-García,3 Consuelo Montejo,4 Emilia Barcia,1,2 Ana Fernández-Carballido1,2 1Department of Pharmaceutics, School of Pharmacy, University Complutense of Madrid, Madrid, Spain; 2Institute
Negro S, Fernández-Carballido A, Marcianes P, García-García L, Barcia E, Montejo C   +5 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Surface potential modulation as a tool for mitigating challenges in SERS-based microneedle sensors. [PDF]

Sci Rep, 2022
Brasiliense V, Park JE, Berns EJ, Van Duyne RP, Mrksich M.   +4 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Low Surface Potential with Glycoconjugates Determines Insect Cell Adhesion at Room Temperature. [PDF]

J Phys Chem Lett, 2022
Matsuzaki T, Terutsuki D, Sato S, Ikarashi K, Sato K, Mitsuno H, Okumura R, Yoshimura Y, Usami S, Mori Y, Fujii M, Takemi S, Nakabayashi S, Yoshikawa HY, Kanzaki R.   +14 more
europepmc   +1 more source