Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Probing nanomechanical, interfacial forces, and surface potential properties of MXene-nanocellulose composites. [PDF]
RSC AdvLi J.
europepmc +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Modulating Surface Potential and Electron/Hole Overlap of Singlet Excited State in Asymmetry End-Capped Dimeric Acceptors for Efficient and Stretchable Organic Solar Cells. [PDF]
Angew Chem Int Ed EnglYou S +12 more
europepmc +1 more source
Surface Potential Modulation in Boronate-Functionalized Magnetic Nanoparticles Reveals Binding Interactions: Toward Magnetophoretic Capture/Quantitation of Sugars from Extracellular Matrix. [PDF]
Langmuir, 2023 Lyons S +5 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Hydrothermal Synthesis and Nanoscale Characterization of Single-Unit-Cell Bi<sub>2</sub>WO<sub>6</sub> Nanosheets: Correlation between Morphology, Adhesion, and Surface Potential. [PDF]
ACS OmegaAlmeida CD +8 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Front-Surface Potential of Platinized <i>p</i>‑InP Photocathodes Probed by Dual-Working-Electrode Measurements. [PDF]
ACS Energy LettYu W, Lewis NS.
europepmc +1 more source
Clinical Utility of Body Surface Potential Mapping in CRT Patients. [PDF]
Arrhythm Electrophysiol Rev, 2021 Sedova K +4 more
europepmc +1 more source