Results 61 to 70 of about 4,007,124 (352)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Elevated-Temperature Tensile Behavior and Properties of Inconel 718 Fabricated by In-Envelope Additive–Subtractive Hybrid Manufacturing and Post-Process Precipitation Hardening

Journal of Manufacturing and Materials Processing
The present study focuses on advancing one of the most popular AM techniques, namely, laser powder bed fusion (LPBF) technology, which has the ability to produce complex geometry parts with minimum material waste but continues to face challenges in ...
Sheida Sarafan, Priti Wanjara, Roger Pelletier, Sila Ece Atabay, Javad Gholipour, Josh Soost, Robert Amos, Prakash Patnaik   +7 more
doaj   +1 more source

Improved surface quality of anisotropically etched silicon {111} planes for mm-scale integrated optics

, 2013
We have studied the surface quality of millimeter-scale optical mirrors produced by etching CZ and FZ silicon wafers in potassium hydroxide to expose the $\{111\}$ planes.
Cotter, J. P., Hinds, E A, Kraft, M, Zeimpekis, I.   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Determination of Optimal Machining Parameters Based on Roughness and Vibration Measurements of Pieces Produced by Whirling on a Lathe Machine

Machines
Worms can be produced using special machines or standard lathes equipped with a whirling thread-cutting device. A blank is placed on the mandrel and tightened using the three-jawed chuck of the standard lathe.
Zlatko Botak, Katarina Pisačić, Marko Horvat, Tanja Tomić   +3 more
doaj   +1 more source

Microstructure and Surface Roughness Connection on Machined Ductile Iron: An Experimental Determination [PDF]

E3S Web of Conferences
Ductile iron is useful for a variety of engineering challenges because of its ductility and high strength. Hence, it is an excellent option if machining is required. After milling operations, however, various surface characteristics could be created, and
Teke Ibrahim T., Oktay Mehmet, Baykara Celalettin, Ertas Ahmet H.   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A novel drifter designed for use with a mounted Acoustic Doppler Current Profiler in shallow environments [PDF]

, 2013
We present a novel design for a surface drifter, mounted with a pulse-coherent Acoustic Doppler Current Profiler (ADCP) for measuring near-surface (depths 0.18-1 m) flows.
Henderson, Stephen M., Mullarney, Julia C.   +1 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source