Results 61 to 70 of about 3,984,716 (355)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Surface Quality Improvement of AA6060 Aluminum Extruded Components through Liquid Nitrogen Mold Cooling

open access: yesMetals, 2018
6xxx aluminum alloys are suitable for the realization of both structural applications and architectural decorative elements, thanks to the combination of high corrosion resistance and good surface finish.
Andrea Francesco Ciuffini   +7 more
doaj   +1 more source

On the Mechanism of the Step Coverage of Blanket Tungsten Chemical Vapor Deposition [PDF]

open access: yes, 1993
In this study, computer modeling of the contact fill process with chemical vapor deposition, (CVD) of tungsten is usedto show the importance of several details on the quality of the fill process. The effect of surface curvature on the stepcoverage of CVD-
Hasper, A., Schmitz, J.E.J.
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Elevated-Temperature Tensile Behavior and Properties of Inconel 718 Fabricated by In-Envelope Additive–Subtractive Hybrid Manufacturing and Post-Process Precipitation Hardening

open access: yesJournal of Manufacturing and Materials Processing
The present study focuses on advancing one of the most popular AM techniques, namely, laser powder bed fusion (LPBF) technology, which has the ability to produce complex geometry parts with minimum material waste but continues to face challenges in ...
Sheida Sarafan   +7 more
doaj   +1 more source

Modelling and simulation of the dynamic cutting process and surface topography generation in nano/micro cutting [PDF]

open access: yes, 2008
In nano/micro cutting process, the surface quality is heavily dependent on all the dynamic factors in machining including those from the material, tooling, cutting parameters, servo accuracy, mechanical structure deformation, and non-linear factors as ...
Cheng, K, Zhou, L
core  

Beyond the Rayleigh scattering limit in high-Q silicon microdisks: theory and experiment [PDF]

open access: yes, 2005
Using a combination of resist reflow to form a highly circular etch mask pattern and a low-damage plasma dry etch, high-quality-factor silicon optical microdisk resonators are fabricated out of silicon-on-insulator (SOI) wafers.
Borselli, Matthew   +2 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

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