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Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican+7 more
wiley +1 more source
A Variational Characterization of Fluid Sloshing with Surface Tension
We consider the sloshing problem for an incompressible, inviscid, irrotational fluid in an open container, including effects due to surface tension on the free surface. We restrict ourselves to a constant contact angle and seek time-harmonic solutions of
Hohenegger, Christel+2 more
core +1 more source
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser+11 more
wiley +1 more source
A surface of an article adapted for relative motion with a fluid environment is finished by coating the surface with a fluid adhesive. The adhesive is covered with a sheet of flexible film material under tension, and the adhesive is set while maintaining
Fehrenkamp, L. G.+3 more
core +1 more source
In this communication we show that the surface tension of the real fluids of the Lennard-Jones type can be obtained from the surface tension of the lattice gas (Ising model) on the basis of the global isomorphism approach developed earlier for the bulk ...
A. Maslechko+7 more
core +1 more source
Dropwise Condensation of Low Surface Tension Fluids on Omniphobic Surfaces
Compared to the significant body of work devoted to surface engineering for promoting dropwise condensation heat transfer of steam, much less attention has been dedicated to fluids with lower interfacial tension.
K. Rykaczewski+10 more
semanticscholar +1 more source
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu+11 more
wiley +1 more source
Surface tension driven convection [PDF]
In a normal gravitational environment, the free surface of a liquid in a container plays a passive role in the transport processes. However, at microgravity, the free surface can become the dominant factor.
Ostrach, S.
core +1 more source
Off-equilibrium surface tension in colloidal suspensions
We study the fingering instability of the interface between two miscible fluids, a colloidal suspension and its own solvent. The temporal evolution of the interface in a Hele-Shaw cell is found to be governed by the competition between the non-linear ...
Cipelletti, Luca+3 more
core +3 more sources