Results 81 to 90 of about 3,615,523 (297)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Changes in Surface Properties of Heat-Treated Phyllostachys pubescens Bamboo
BioResources, 2015 The wetting phenomena and surface energetic behavior in heat-treated bamboo were studied. The bamboo specimens were heat-treated at temperatures of 100, 140, and 180 °C for 4 h, and an untreated sample served as a control.
Yamei Zhang, Wenji Yu
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Measurement of free surface energy of laser treated aluminum substrate
MATEC Web of Conferences, 2017 The change in the surface energy of the aluminum substrate after laser treatment has been determined experimentally. Surface energy is determined using the Advance KRUSS software.
Batishcheva Kseniya +3 more
doaj +1 more source
Milling of Heat-Treated Beech Wood (Fagus sylvatica L.) and Analysis of Surface Quality
BioResources, 2016 Several previous studies have investigated the effects of heat treatment on the chemical composition, along with the physical and mechanical properties, of wood from various species.
Mihai Ispas +4 more
doaj +1 more source
Horizon Formation in High-Energy Particles Collision
, 2008 We investigate a classical formation of a trapped surface in 4-dimensional flat space-time in a process of a non-head-on collision of two high-energy particles which are treated as Aichelburg-Sexl shock waves.
Cavaglia M Das S +9 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source