Results 101 to 110 of about 3,615,523 (297)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Surface Modification of Polymers Treated by Various Fluorinating Media

open access: yesActa Chimica Slovenica, 2013
Fluorination processes of polymer surfaces are able to lead to drastic modifications of the surface properties without changing the bulk characteristics of the virgin material. In this paper, two types of polymers, i.e.
Alain Tressaud   +6 more
doaj  

Ceramic fabrication process before firing-surface treatment of ceramic powder [PDF]

open access: yes
The surface treatment of powders is discussed. Stability of ceramic powders and surfaces and the improvement of moldability are addressed. Characteristics of surface treatment technology are given, including formation of inorganic surface-treated layers,
Tsunoda, T.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Surface functionalization of medical-grade polyvinyl chloride treated with ammonia plasma

open access: yesResults in Surfaces and Interfaces
Polyvinyl chloride (PVC) is often the material of choice for the synthesis of various components used in medical practice, particularly catheters. As-synthesized components may not exhibit appropriate biocompatibility, so the surface should be modified ...
Rok Zaplotnik   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Surface Substructure and Properties of ZrB2p/6061Al Composite Treated by Laser Surface Melting under Extreme Cooling Conditions

open access: yesHigh Temperature Materials and Processes, 2017
Particulate reinforcement composite ZrB2p/6061Al was fabricated from Al-K2ZrF6-KBF4 by a direct melt reaction. Laser surface melting was used to improve the surface strength of the in situ ZrB2p/6061Al composite, which includes a series of laser-melted ...
Zeng Yida   +9 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications

open access: yesInternational Journal of Nanomedicine, 2019
Diego Pedreira de Oliveira,1,* Tatiane Venturott Toniato,2 Ritchelli Ricci,2 Fernanda Roberta Marciano,3 Egor Prokofiev,4 Ruslan Z Valiev,4,5 Anderson Oliveira Lobo,6,* Alberto Moreira Jorge Júnior1,7,* 1Department of Materials Engineering ...
Oliveira DP   +7 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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