Results 91 to 100 of about 5,030,159 (295)

Groundwater Origin and Dynamics on the Eastern Flank of the Colorado River Delta, Mexico

, 2021
Isotope data and major ion chemistry were used to identify aquifer recharge mechanisms and geochemical evolution of groundwaters along the US–Mexico border.
Christopher J. Eastoe, Karl W. Flessa, Jennifer C. McIntosh, Hector A. Zamora   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Combined Earth observations reveal the sequence of conditions leading to a large algal bloom in Lake Geneva

Communications Earth & Environment
Freshwater algae exhibit complex dynamics, particularly in meso-oligotrophic lakes with sudden and dramatic increases in algal biomass following long periods of low background concentration.
Abolfazl Irani Rahaghi, Daniel Odermatt, Orlane Anneville, Oscar Sepúlveda Steiner, Rafael Sebastian Reiss, Marina Amadori, Marco Toffolon, Stéphan Jacquet, Tristan Harmel, Mortimer Werther, Frédéric Soulignac, Etienne Dambrine, Didier Jézéquel, Christine Hatté, Viet Tran-Khac, Serena Rasconi, Frédéric Rimet, Damien Bouffard   +17 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

[Report to R. H. Lunday by B. M. Waters #1]

, 1966
Report by B. M. Waters, Detective in Charge, to R. E. Lunday, Deputy Chief Commanding of the Criminal Investigation Division. In the report, Waters describes a phone call received from Mr. James Hacker.
Dallas (Tex.). Police Department.
core  

REE fractionation during granite weathering and removal by waters and suspended loads: Sr and Nd isotopic evidence [PDF]

, 2001
Very few studies deal with REE (rare earth element) mobility within the system soil–soil solution–streamwater. In this article, we try to characterize the fractionation and the migration of the REE in a granite-derived soil system located in a small ...
Dominique Aubert, Aubert, Dominique, Anne Probst, Stille, Peter, Probst, Anne, Peter Stille   +5 more
core   +1 more source

DEPHENOLIZATION OF GEOTHERMAL WATERS BEFORE DISCHARGING INTO SURFACE WATERS

Юг России: экология, развитие, 2017
. Aim. Dephenolization of geothermal waters before discharging into open reservoirs. Methods. Technological solutions are proposed for utilization of spent geothermal phenol-containing waters by using ozone and activated carbon for solving the ...
Dzhabrail R. Chalaev, Nariman D. Chalaev
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Occurrence of glucocorticogenic activity in various surface waters in The Netherlands

, 2013
Considering the important role that surface waters serve for drinking water production, it is important to know if these resources are under the impact of contaminants.
Schriks, M., de Voogt, P.; id_orcid, Heringa, M.B., van der Linden, S.C., van der Burg, B., Stoks, P.G.M., Puijker, L., de Voogt, P.   +7 more
core   +1 more source

Impacts of Extreme Weather on Sea Surface Temperature in the Western Waters of Sumatera and the Southern Waters of Java in June 2016

Forum Geografi, 2017
Ocean dynamics is affected by atmospheric conditions. Surface wind is one of atmospheric variables that has an important role in the ocean dynamics.
Martono Martono
doaj   +1 more source