Results 111 to 120 of about 247,498 (307)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Key bacterial groups maintain stream multifunctionality in response to episodic drying
Limnology and Oceanography LettersMicrobial biodiversity is fundamental to maintain ecosystem functioning in seasonally variable ecosystems. However, it remains unclear how alterations in water availability caused by episodic drying compromise the ability of stream microbes to maintain ...
Giulia Gionchetta +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Proceedings from the Workshop on Heavy Metals (Pb, Cd and Hg) in Surface Waters Monitoring and Biological Impact. March 18 - 20, 2002, Lillehammer, Norway (ICP Waters report 67/2002) [PDF]
, 2002 This report contains the proceedings from the Workshop on Heavy Metals (Pb, Cd and Hg) in Surface Waters Monitoring and Biological Impact.
Skjelkvåle, B.L., Ulstein, M.J.
core
Sea surface temperature changes in the southern California borderlands during the last glacial-interglacial cycle [PDF]
, 1996 A variety of evidence suggests that average sea surface temperatures (SSTs) during the last glacial maximum in the California Borderlands region were significantly colder than during the Holocene.
P. Graham Mortyn +9 more
core +2 more sources
Frontiers in Remote SensingGiven the use of machine learning-based tools for monitoring the Water Quality Indicators (WQIs) over lakes and coastal waters, understanding the properties of such models, including the uncertainties inherent in their predictions is essential.
Arun M. Saranathan +8 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Estimation of phytoplankton concentration from downwelling irradiance measurements in water [PDF]
, 2012 The downwelling irradiance spectrum is so far not used directly for the determination of water constituents, mainly due to the large and unpredictable fluctuations of the underwater light field induced by the water surface.
Gege, Peter
core +1 more source
Possibilities of surface waters monitoring at mining areas using UAV
E3S Web of Conferences, 2018 The selected, remote measurement methods are discussed, useful for determining surface water properties using mobile unmanned aerial platforms (UAV). The possibilities of using this type of solutions in the scope of measuring spatial, physicochemical and
Lisiecka Ewa +4 more
doaj +1 more source