Results 101 to 110 of about 247,498 (307)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Combined Earth observations reveal the sequence of conditions leading to a large algal bloom in Lake Geneva

Communications Earth & Environment
Freshwater algae exhibit complex dynamics, particularly in meso-oligotrophic lakes with sudden and dramatic increases in algal biomass following long periods of low background concentration.
Abolfazl Irani Rahaghi, Daniel Odermatt, Orlane Anneville, Oscar Sepúlveda Steiner, Rafael Sebastian Reiss, Marina Amadori, Marco Toffolon, Stéphan Jacquet, Tristan Harmel, Mortimer Werther, Frédéric Soulignac, Etienne Dambrine, Didier Jézéquel, Christine Hatté, Viet Tran-Khac, Serena Rasconi, Frédéric Rimet, Damien Bouffard   +17 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

DEPHENOLIZATION OF GEOTHERMAL WATERS BEFORE DISCHARGING INTO SURFACE WATERS

Юг России: экология, развитие, 2017
. Aim. Dephenolization of geothermal waters before discharging into open reservoirs. Methods. Technological solutions are proposed for utilization of spent geothermal phenol-containing waters by using ozone and activated carbon for solving the ...
Dzhabrail R. Chalaev, Nariman D. Chalaev
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Brewster-angle measurements of sea-surface reflectance using a high resolution spectroradiometer [PDF]

, 2002
This paper describes the design, construction and testing of a ship-borne spectroradiometer based on an imaging spectrograph and cooled CCD array with a wavelength range of 350-800 nm and 4 nm spectral sampling.
Woods, P.J., Peter Wood, Woods, Peter, David McKee, McKee, David, McKee, D., Alex Cunningham, Cunningham, Alex, Cunningham, A.   +8 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chemical and biological recovery in acid-sensitive waters: trends and prognosis (ICP Waters report 119/2015) [PDF]

, 2015
We present a trend analysis of surface water chemistry in in acid-sensitive lakes and rivers in Europe and North America, for the period 2000 to 2011, combined with a prognosis for water chemistry in Europe in 2020.
Fjellheim, A, de Wit, Heleen, Garmo, Øyvind Aaberg   +2 more
core  

and waters carry it [PDF]

, 2023
and waters carry it performance: rocks, steamer, galvanised stainless steel pan, moseley bog water, microscopic algae slides, paper, metal racks, hot plate, card.
Sharples, V.
core  

Impacts of Extreme Weather on Sea Surface Temperature in the Western Waters of Sumatera and the Southern Waters of Java in June 2016

Forum Geografi, 2017
Ocean dynamics is affected by atmospheric conditions. Surface wind is one of atmospheric variables that has an important role in the ocean dynamics.
Martono Martono
doaj   +1 more source