Results 71 to 80 of about 316,671 (311)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
On the class of projective surfaces of general type
Hokkaido Mathematical Journal, 2017 Let $S$ be a smooth complex projective surface of general type, $H$ be a very ample divisor on $S$ and $m(S,H)$ be the class of $(S,H)$. In this paper, we study a lower bound for $m(S,H)-3H^2$ and we improve an inequality obtained by Lanteri. We also study $(S,H)$ with each value of $m(S,H)-3H^2$ and exhibit some examples.
FUKUMA, Yoshiaki, ITO, Kazuhisa
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Le Matematiche, 2010 Let $(X,L)$ be a quasi-polarized surface.In our previous papers, we studied $(X,L)$ with $\kappa(X)=2$, $h^{0}(L)>0$ and $g(X,L)=h^{1}(\mathcal{O}_{X})$.Here $g(X,L)$ denotes the sectional genus of $(X,L)$.In this note, we give the classification of ...
Yoshiaki Fukuma
doaj
Frontiers in Earth ScienceThe evolution processes of locked-segment landslides are difficult to determine, causing severe economic losses and casualties. Furthermore, when the locked-segment landslide is excavated, its evolution process will become more complicated.
Xiaochao Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Geometric k-normality of curves and applications
Le Matematiche, 2003 The notion of geometric k-normality for curves is introduced in complete generality and is investigated in the case of nodal and cuspidal curves living on several types of surfaces.
Alessandro Arsie, Concettina Galati
doaj
On the classification of numerical Godeaux surfaces with an involution
, 2004 Report on a work in progress, with M. Mendes Lopes, about the classification of numerical Godeaux surfaces (i.e. minimal algebraic surfaces of general type with vanishing geometric genus and bi-genus equal to 2) with an automorphism of order ...
CALABRI, Alberto, C. Ciliberto
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The scale free and scale - bound properties of land surfaces: fractal analysis and specific geomorphometry from digital terrain models [PDF]
, 1990 The scale-bound view of landsurfaces, being an assemblage of certain landforms, occurring within limited scale ranges, has been challenged by the scale-free characteristics of fractal geometry.
McClean, Colin John
core