Results 121 to 130 of about 592,753 (266)

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Expert consensus on treatment of condylar hyperplasia and secondary dento-maxillofacial deformities. [PDF]

Int J Oral Sci
Bi R, Abotaleb BM, Bai X, Cao K, Chen G, Cheng J, Guo W, Hu M, Huang L, Huang X, Jiang H, Jiang L, Jin X, Kang F, Li T, Li W, Liu S, Liu Y, Liu Y, Lu L, Shao Y, Shi B, Song G, Su Y, Sun J, Tang Z, Tian L, Tuerdi M, Wan Q, Wang X, Wang X, Wang Y, Wu G, Xie Z, Yan G, Yang X, You M, Zhang F, Zhang S, Zheng G, Zhu S, Luo E.   +41 more
europepmc   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

Oral oxycodone versus sublingual buprenorphine for postoperative pain control after pelvic exenteration (PROSPER): a pilot, registry-embedded, multi-centre, double-blind, placebo-controlled, randomised controlled trial. [PDF]

BMJ Open
Johnstone C, Koh C, Mathieson S, Steffens D, White K, Gray P, Harris C, Heriot A, Kramer K, Law CK, Lin CC, Liu X, Machado G, McLachlan A, Penm J, Riedel B, Sammour T, Sanders R, Solomon M, Whitehead L, Winter D, Young J, Patanwala A.   +22 more
europepmc   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Correction: Quality assurance in orthognathic surgery using Brons-Mulié's soft tissue analysis, Nakamura's asymmetry index and a simple enface analysis. [PDF]

Front Oral Health
Frontiers Production Office.
europepmc   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

A multicentric prospective analysis of the management of edentulous jaw fractures in the elderly population: a World Oral Maxillofacial Trauma (WORMAT) project. [PDF]

Oral Maxillofac Surg
Roccia F, Omedè M, Sobrero F, Cremona G, Yilmaz UN, Atabay M, Bourazani M, Skiadas S, Kovačič Ž, Krebs N, Sivrić A, Kordić M, Bottini GB, Goetzinger M, de Oliveira Gorla LF, Pereira-Filho VA, Dediol E, Kos B, Konstantinovic VS, Miković N, Samieirad S, Roig AM, Ferran AP, Laverick S, Mehmet T, Benech R, Dmd MT, Strada C, Jaisani MR, Hassanein AG, Allam MS, Fwacs TA, Volpe F, Copelli C.   +33 more
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Corrigendum to 'Significance of methyltransferase-like 5 expression in oral squamous cell carcinoma' [Volume 76, Issue 3, June 2026, 109533]. [PDF]

Int Dent J
Kajiya Y, Shima K, Shimojukkoku Y, Oku Y, Tsuchiyama T, Higashimoto K, Kurihara-Shimomura M, Sasahira T.   +7 more
europepmc   +1 more source