Results 41 to 50 of about 6,605,440 (312)

Clinical indicators for the incidence of postoperative ileus after elective surgery for colorectal cancer [PDF]

, 2021
Yosuke Namba, Yuzo Hirata, Shoichiro Mukai, Sho Okimoto, Seiji Fujisaki, Mamoru Takahashi, Toshikatsu Fukuda, Hideki Ohdan   +7 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Assessment of Hand Hygiene Knowledge, Attitude, and Practice Among Health Sciences Students in Herat, Afghanistan: A Cross-Sectional Study

Risk Management and Healthcare Policy
Enayatollah Ejaz,1 Mohammad Masudi,1,2 Ali Rahimi,1– 3 Khadejah Osmani,4 Nasar Ahmad Shayan5 1Department of Curative Medicine, Faculty of Medicine, Jami University, Herat, Afghanistan; 2Department of Pediatrics, Faculty of Medicine, Herat University ...
Ejaz E, Masudi M, Rahimi A, Osmani K, Shayan NA   +4 more
doaj  

The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation

Annals of Surgery, 2017
Objective: The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery.
M. Abu Hilal, L. Aldrighetti, I. Dagher, B. Edwin, R. Troisi, R. Alikhanov, S. Aroori, G. Belli, M. Besselink, J. Briceño, B. Gayet, M. D’Hondt, M. Lesurtel, K. Menon, P. Lodge, F. Rotellar, J. Santoyo, O. Scatton, O. Soubrane, R. Sutcliffe, R. V. van Dam, S. White, M. Halls, F. Cipriani, M. J. van der Poel, R. Ciria, L. Barkhatov, Yrene Gomez-Luque, Sira Ocana-Garcia, A. Cook, J. Buell, P. Clavien, C. Dervenis, G. Fusai, D. Geller, H. Lang, J. Primrose, Mark A. Taylor, T. V. van Gulik, G. Wakabayashi, H. Asbun, D. Cherqui   +41 more
semanticscholar   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The Application of Retrograde Intrarenal Surgery to Remove a Single Large Kidney Stone During Pregnancy [Corrigendum]

Research and Reports in Urology
Jongjitaree K, Taweemonkongsap T, Leewansangtong S, Srinualnad S, Chotikawanich E. Res Rep Urol. 2020;12:351–355. Page 354, Ethical Approval section, the text “The publication of this study was approved by the Ethics Committee of ...
Jongjitaree K, Taweemonkongsap T, Leewansangtong S, Srinualnad S, Chotikawanich E   +4 more
doaj