Results 71 to 80 of about 6,584,741 (301)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Regret after Gender-affirmation Surgery: A Systematic Review and Meta-analysis of Prevalence

, 2021
Valeria P. Bustos, Samyd S. Bustos, Andrés Mascaró, Gabriel Del Corral, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Howard N. Langstein, Oscar J. Manrique   +8 more
openalex   +1 more source

Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis

Journal of Inflammation Research
Yingna Mei,1 Yitao Zheng,2 Xingfen Zhang,1 Ting Hu,1 Xiaoqing Zheng,1 Cui Zhang,3 Qinzhi Deng1 1Department of Liver Disease, Ningbo No.2 Hospital, Ningbo, People’s Republic of China; 2Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo
Mei Y, Zheng Y, Zhang X, Hu T, Zheng X, Zhang C, Deng Q   +6 more
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction [PDF]

, 2011
Eric J. Velazquez, Kerry L. Lee, Marek Deja, Anil Jain, George Sopko, А. В. Марченко, Imtiaz S. Ali, Gerald Pohost, Siniša Gradinac, William T. Abraham, Michael Yii, Dorairaj Prabhakaran, Hanna Szwed, Paolo Ferrazzi, Mark C. Petrie, Christopher M. O’Connor, Pradit Panchavinnin, Lilin She, Robert O. Bonow, Gena Roush Rankin, Robert H. Jones, Jean-Lucien Rouleau   +21 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A comparison of cardiac output derived from the arterial pressure wave against thermodilution in cardiac surgery patients † [PDF]

, 2001
J. R. C. Jansen, J. J. Schreuder, J. P. Mulier, N. Ty Smith, J. J. Settels, Karel H. Wesseling   +5 more
openalex   +1 more source

Obstructing finite surgery [PDF]

, 2013
For a fixed p, there are only finitely many elliptic 3-manifolds given by p/q-surgery on a knot in S^3. We prove this result by using the Heegaard Floer correction terms (d-invariants) to obstruct elliptic manifolds from arising as knot surgery.Comment ...
Doig, Margaret I.
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source