Results 111 to 120 of about 5,970,578 (344)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Virtual reality and biofeedback in surgical training: a review and proposal for comparative study between novice and experienced surgeons [PDF]

Journal of Biomedical & Clinical Research
Virtual reality (VR) is increasingly adopted in surgical education as a safe and controlled environment for developing technical and non-technical skills. Parallel to this, physiological biofeedback has emerged as a promising method for assessing stress,
Martin Karamanliev, Meri Shoshkova, Stefka Petrova, Dobromir Dimitrov, Stoyan Vezenkov   +4 more
doaj   +3 more sources

Surgical Research IV

Journal of Investigative Surgery, 2010
In the "Importance of Medical and Surgical Research" (Surgical Research I), we introduced research as the key factor in the advancement of medicine and surgery. In Surgical Research II, we presented William Beaumont, Samuel Gross, and William Halsted as the main protagonists of the first wave of American surgical researchers during the 19th and early ...
openaire   +4 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Preventing and treating surgical site infection in patients with spinal metastatic disease [PDF]

, 2013
Surgery to remove secondary spinal tumours is often necessary to relieve symptoms associated with metastatic spinal cord compression (MSCC). However, such individuals are at high risk of surgical site infection (SSI).
Lui, Steve, Atkinson, Ross, Ousey, Karen
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effects of SGLT2 Inhibitors on Cardiovascular and Lower Limb Events in Patients with Type 2 Diabetes: A Nationwide Population-Based Study

Diabetes, Metabolic Syndrome and Obesity
Min Jin Lee,1,2,* Ji Hyun Bae,1,2,* Ah Reum Khang,1,2 Yang Ho Kang,1,2 Joo Yeon Kim,1,2 Su Hyun Kim,1,2 Soo Yong Lee,2,3 Seung Hun Woo,2,4 Minae Park,5 Sojeong Park,5 Dong Hee Kim,2 Dasol Kang,2 Sujin Park,2 Dongwon Yi1,3 1Division of ...
Lee MJ, Bae JH, Khang AR, Kang YH, Kim JY, Kim SH, Lee SY, Woo SH, Park M, Park S, Kim DH, Kang D, Park S, Yi D   +13 more
doaj  

A method for clustering surgical cases to allow master surgical scheduling [PDF]

Master surgical scheduling can improve manageability and efficiency of operating room departments. This approach cyclically executes a master surgical schedule of surgery types.
Oostrum, J.M. van, Kazemier, G., Wagelmans, A.P.M., Parlevliet, T.   +3 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Diamond-like carbon coating of alternative metal alloys for medical and surgical applications [PDF]

, 2010
The effectiveness of a plasma-deposited, diamond-like carbon (DLC) coating on aluminium alloy based surgical instruments is investigated. Surgical instruments must satisfy a number of important criteria including biocompatibility, functional performance,
Bulpett, R, Reynolds, AJ, Franks, J, Jones, Benjamin, Anson, AW, Jones, B J, Anson, A W, Jones, BJ, Mahendran, A, Reynolds, A J   +9 more
core   +1 more source