Results 111 to 120 of about 6,742,024 (351)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Assessment of antimicrobial prescribing patterns, guidelines compliance, and appropriateness of antimicrobial prescribing in surgical-practice units: point prevalence survey in Malaysian teaching hospitals

Frontiers in Pharmacology
Objectives: This study sought to investigate the quality of antimicrobial prescribing among adult surgical inpatients besides exploring the determinants of non-compliance and inappropriate prescribing to inform stewardship activities.Methods: A cross ...
Nurul Adilla Hayat Jamaluddin, Nurul Adilla Hayat Jamaluddin, Petrick Periyasamy, Chee Lan Lau, Chee Lan Lau, Sasheela Ponnampalavanar, Pauline Siew Mei Lai, Pauline Siew Mei Lai, Ly Sia Loong, Tg Mohd Ikhwan Tg Abu Bakar Sidik, Ramliza Ramli, Toh Leong Tan, Najma Kori, Mei Kuen Yin, Nur Jannah Azman, Rodney James, Rodney James, Karin Thursky, Karin Thursky, Isa Naina Mohamed   +19 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Role of Peer Review in Surgical Research

The Annals of African Surgery, 2023
Vincent Kipkorir, Stanley Aruyaru, James Kigera   +2 more
doaj   +1 more source

Alterações funcionais do fígado após derivação porto-cava e hepatectomia parcial: Estudo experimental em cães

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Estudar os efeitos da derivação porto-cava sobre a função hepática de cães. MÉTODO: Vinte animais foram divididos em dois grupos: o Grupo I foi submetido à hepatectomia parcial de 28,7% e o Grupo II, à hepatectomia parcial associada à derivação
Valdinaldo Aragão de Melo, Reginaldo Ceneviva, Álvaro Queiroz de Godoy, José Ernesto dos Santos, Gustavo Barreto de Melo   +4 more
doaj   +1 more source

Cadaveric simulation for improving surgical training in dermatology. [PDF]

, 2018
Simulation models are rapidly changing medical education, especially the training of dermatology residents. Various models are available, including cadaveric simulations.
Connolly, Deirdre, Griffin, Thomas, Hazan, Ezra, Keller, Matthew, Torbeck, Richard, Trufant, Joshua, Wang, Jordan V.   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Pain management in surgical patients [PDF]

, 2011
Acute post-operative pain is a major problem which is not well addressed clinically; with patients regularly reporting significant pain following surgery (Clark, 2006). The possible harmful effects of untested surgical pain include: deep vein thrombosis,
Bonnell, Shanna R.
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source