Results 91 to 100 of about 34,602 (289)

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target. [PDF]

, 2018
Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy.
Dorff, Tanya, Jolly, Mohit Kumar, Kulkarni, Prakash, Lau, Clayton, Orban, John, Salgia, Ravi, Weninger, Keith   +6 more
core   +3 more sources

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

Transcriptomic profiling reveals differential muscle development and metabolic regulation in male Xizang sheep subjected to surgical vs. GnRH-immunocastration

Italian Journal of Animal Science
Castration is a common treatment modality for livestock and poultry; however, the conventional surgical method not only compromises animal welfare but also significantly impacts the economic viability of farming operations.
Tianzeng Song, Xiaoming Zhang, Gaofu Wang, Guiqiong Liu, Shehr Bano Mustafa, Khuram Shahzad, Xiaoying Chen, Ming Zhang, Xianyin Zeng, Mengjun Liu, Jianzhao Cui, Wangsheng Zhao, Xunping Jiang   +12 more
doaj   +1 more source

Self-Administration of Meloxicam via Medicated Molasses Lick Blocks May Improve Welfare of Castrated Calves

Animals
The self-administration of meloxicam via medicated feed is a novel concept that could enable non-invasive, pre-emptive and long-term analgesia. Forty Bos taurus male calves were randomly allocated to four treatment groups: no castration (PC), surgical ...
Samantha Rudd, Sabrina Lomax, Peter J. White, Dominique Van der Saag   +3 more
doaj   +1 more source

Correlation between the presence of the nuclear AR-V7 androgen receptor and clinical evolution of prostate cancer: in vitro analysis of a combination of compounds targeting PI3K [PDF]

, 2019
Introduzione: PCa è una malattia multiforme e biologicamente molto eterogenea. Diversi meccanismi chiave nella progressione della malattia da androgeno-dipendente ad androgeno-indipendente (CRCP) possono essere attribuiti ad alterazione nella via di ...
Cattarino, Susanna
core  

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Effects of neonatal surgical castration and immunocastration in male pigs on blood T lymphocytes and health markers

Animal, 2014
Surgical castration in pig husbandry is criticized for welfare reasons. Thus, it is necessary to evaluate alternative ways of rearing male pigs, such as entire or immunocastrated animals.
C. Leclercq, A. Prunier, E. Merlot
doaj   +1 more source

Evaluation of the effect of surgical and immunological castration of male pigs on boar taint compounds in oral fluid and fat tissue by LC-MS/MS method

Journal of Veterinary Research, 2020
An effective way of preventing undesirable boar taint in pork meat caused by the presence of androstenone, skatole and indole is surgical castration of piglets. This, however, arouses growing social opposition.
Woźniak Barbara, Cybulski Piotr, Jabłoński Artur, Witek Sebastian, Matraszek-Żuchowska Iwona   +4 more
doaj   +1 more source

Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients [PDF]

, 2013
We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression.
Black, Callewaert, Chen, Claire Adams, Clare Orange, Fu, Gaughan, Gioeli, Gioeli, Gordon, Hsu, Jennifer Willder, Joanne Edwards, Kirkegaard, Lin, Lindsay Bennett, Mahajan, Mark Underwood, Mccall, Mccall, Mellinghoff, Pamela McCall, Ponguta, Rochette-Egly, Shigemura, Tahir Qayyum, Tam, Taneja, Traynor, Van Laar, Wen, Willder, Wong, Zhou, Zong   +34 more
core   +3 more sources

Effect of butorphanol in combination with xylazine during castration of calves: A randomised trial under field conditions

Veterinary Record, EarlyView.
Abstract Background In horses, cats and dogs, the opioid butorphanol has been proven effective in management of visceral pain and for peri‐ and postoperative pain relief. The aim of this study was to evaluate physiological responses and indicators of noxious stimuli when adding butorphanol to xylazine for sedation of bull calves during surgical ...
Axel Sannö, Lovisa Snygg, Maja Wiklund, Görel Nyman   +3 more
wiley   +1 more source