Results 61 to 70 of about 34,602 (289)

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Economical impact of orchiectomy for advanced prostate cancer

International Brazilian Journal of Urology, 2003
PURPOSE: To demonstrate the economical impact of surgical castration in comparison to the medical castration for patients with advanced prostate cancer.
Paula Adriano A. P. de, Piccelli Hilton R. S., Pinto Nilson P., Teles Antonio G., Franqueiro Antonio G., Maltez Adriano R. L., Silva Jose H.   +6 more
doaj  

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Local anesthesia in piglets undergoing castration-A comparative study to investigate the analgesic effects of four local anesthetics on the basis of acute physiological responses and limb movements.

PLoS ONE, 2020
Surgical castration of male piglets without analgesia is a painful procedure. This prospective, randomized and double-blinded study aimed to evaluate the analgesic effects of four different local anesthetics for piglet castration during the first week of
Anna M Saller, Julia Werner, Judith Reiser, Steffanie Senf, Pauline Deffner, Nora Abendschön, Christine Weiß, Johannes Fischer, Andrea Schörwerth, Regina Miller, Yury Zablotski, Shana Bergmann, Michael H Erhard, Mathias Ritzmann, Susanne Zöls, Christine Baumgartner   +15 more
doaj   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Sex Offender Treatment Project: Literature Review [PDF]

, 1994
A comprehensive literature review on recidivism by and the treatment of sex offenders.Alaska Department of CorrectionsAcknowledgements / Introduction / Recidivism / Treatment — Voluntary Vs. Involuntary, Treated Vs.
Baca, Melanie, Barnes, Allan R., Dix, Melody, Flahr, Shelly, Gaal, Cathy, Moeglein, Samantha, Morgheim, Nicol, Whitaker, Max   +7 more
core  

Comparing the efficacy of dextrose, mannitol, and saline solutions in male rabbits' chemical castration

Animal Models and Experimental Medicine, EarlyView.
Our study demonstrated that a single bilateral intra‐testicular injection of 50% dextrose (Group A) and 20% mannitol (Group B) solutions cannot serve as chemical sterilizing agents in male rabbits. However, intra‐testicular injection of 0.9% saline (Group C) significantly reduced the seminiferous tubule quality (STQ), seminiferous tubule maturity (STM),
Mohammad‐Javad Gholizadeh, Reza Azargoun, Ali Shalizar‐Jalali   +2 more
wiley   +1 more source

Introduction [PDF]

, 2018
Crime-preventing neurointerventions (CPNs) are increasingly being used or advocated for crime prevention. There is increasing use of testosterone-lowering agents to prevent recidivism in sexual offenders, and strong political and scientific interest in ...
Birks, David, Douglas, Thomas
core  

Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment [PDF]

, 2004
Objective To establish which attributes of conservative treatments for prostate cancer are most important to men. Design Discrete choice experiment. Setting Two London hospitals. Participants 129 men with non-metastatic prostate cancer, mean age 70 years;
Bryan, S., de Winter, P., Emberton, M., Fry, P., Payne, H., Sculpher, M.   +5 more
core   +2 more sources

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source