Results 181 to 190 of about 1,023,614 (265)

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy, Annette Sereika, Karen Kaul, Megan Parilla, Mir B. Alikhan, Michael Bouma, Dyson Wake, Peter J. Hulick, Henry M. Dunnenberger, Linda M. Sabatini, Mathew Yang, Kathy A. Mangold, Erin Proctor, Nicholas Evans, Nicholas Miller, Donald L. Helseth Jr, Darryck Maurer, Justin Brueck, Janardan Khandekar, Bruce Brockstein   +19 more
wiley   +1 more source

Spinal Mechanisms of Testosterone Involved in Itch Regulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Testosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Luying Chen, Xiaodong Wang, Lu Cheng, Pengtao Li, Zhenyu Wu, Hui Li   +5 more
wiley   +1 more source

Use of Meloxicam or Ketoprofen for Piglet Pain Control Following Surgical Castration. [PDF]

Front Vet Sci, 2018
Viscardi AV, Turner PV.
europepmc   +1 more source

Spatiotemporal transcriptomics for tumour microenvironment remodelling in cancer progression and therapy

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review summarises how spatial transcriptomics technologies reveal tumour microenvironment heterogeneity and support the inference of dynamic remodelling during cancer progression. Abstract Background Spatiotemporal transcriptomics (STT) integrates spatially resolved gene expression with temporal information derived from staged samples, paired ...
Ying Kang, Qinjing Wang, Siqi Xu, Jiming Guo, Yue Ming, Weixing Chen, Min Wang, Zhijie Huang, Yisheng Huang, Bo Jia   +9 more
wiley   +1 more source

The age of surgical castration affects the healing process in beef calves. [PDF]

Transl Anim Sci, 2017
Norring M, Mintline EM, Tucker CB.
europepmc   +1 more source

Integrating Transcriptomic and Proteome Analysis to Understand Muscle Qualities and Related Regulatory Factors of Holstein Beef Under Transportation Stress

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
In Holstein steers subjected to 15 h of long‐distance transportation, beef exhibited marked differences in meat quality, myofibrillar structure, and flavor components compared with cattle slaughtered without prior transport. These differences included significantly increased shear force, water loss rate, and drip loss, shortened sarcomere length, and ...
Zhaomin Lei, Siyu Cheng, Ruixin Yang, Jinping Shi, Zemin Li, Wangjing Liu   +5 more
wiley   +1 more source

Sarcopenia Is Associated With Severe Treatment Toxicity and Mortality in Older Adults With Advanced Cancer: A Secondary Analysis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Sarcopenia, a loss of muscle strength, quantity and performance that occurs primarily from ageing or secondary to disease, is hypothesized to worsen treatment outcomes in patients with cancer. Most published studies, however, focus solely on muscle quantity in patients under 70.
Lindsey J. Mattick, Mostafa Mohammed, Chin‐Shang Li, Rachael G. Tylock, Kah Poh Loh, Marie A. Flannery, Luke J. Peppone, Po‐Ju Lin, Marcus D. Goncalves, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Karteek Popuri, Mirza Faisal Beg, James D. Bearden, Jeffrey Berenberg, Khalil Katato, Karen M. Mustian, Supriya G. Mohile, Richard F. Dunne   +18 more
wiley   +1 more source

Longitudinally Monitoring Prostate Cancer Bone Metastasis and Treatment Response via Circulating Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Lethal prostate cancer (PCa) is dominated by treatment‐refractory progression in bone. In this study, we used plasma‐derived extracellular vesicles (EVs) for monitoring the tumour and therapy‐induced changes in the bone tumour microenvironment (bone‐TME) in men with bone metastatic PCa (M1b PCa).
Emanuela Gentile, Paul G. Corn, Martha Zavridou, James P. Long, Jian H. Song, Anh Hoang, Andrew W. Hahn, Eleonora Dondossola, William Norton, Sue‐Hwa Lin, Christopher J. Logothetis, Theocharis Panaretakis   +11 more
wiley   +1 more source

Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
A whole‐body map of sEVs from a single pig, including 133 samples spanning 10 systems, revealed striking tissue‐specific heterogeneity in yield. Importantly, a conserved core cargo set comprising candidate sEV markers (ACTG1, CFL1, and ANXA2), RNA‐binding proteins, the let‐7 miRNA family, and ferritin genes was defined from 105,409 (88.6% full‐length ...
Naixiang Yu, Jinxiu Liu, Chenliang Lai, Siyi Liu, Jiacheng Wei, Jiahong Zhong, Sanya Xiong, Qingjie Zeng, Junwu Ma, Zhou Zhang, Zhiyan Zhang   +10 more
wiley   +1 more source