Results 121 to 130 of about 91,170 (329)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Factors associated with secondary thoracotomy for hemostasis following lung surgery: a retrospective analysis

Frontiers in Oncology
PurposeThis study aimed to systematically investigate the causes and management of secondary thoracotomy for hemostasis following lung cancer surgery. Although infrequent, secondary thoracotomy can lead to prolonged hospitalization, increased costs, and ...
Junwei Xie, Junwei Xie, Junwei Xie, Hongliang Wang, Tianci Han, Wei Tong, Xiaoqi Guo, Min Zhang, Dongzhe Liu, Liang Zhang, Liang Zhang, Liang Zhang, Hongxu Liu, Hongxu Liu, Hongxu Liu   +14 more
doaj   +1 more source

Bio‐Inspired Micro‐Fin‐Assisted Multi‐Modal Vascular Intervention

Advanced Science, EarlyView.
A magnetic guidewire with a micro‐fin–integrated tip is introduced for multimodal cardiovascular navigation. The micro‐fins exploit fluid drag to augment magnetic torque, enabling bifurcation traversal at 15 mT, tolerating 45° misalignment, bidirectional crawling, and buckle self‐correction.
Xu Liu, Qiang Luo, Zhuoqun Cao, Hongde Li, Xi Chen, Hong Wang, Mao Chen, Ziyu Ren, Wenqi Hu   +8 more
wiley   +1 more source

A new bipolar blood sealing system embedded in perioperative strategies vs. a conventional regimen for total knee arthroplasty: results of a matched-pair study

GMS German Medical Science, 2005
From a prospective matched-pair study in 40 patients it can be concluded that the use of a new bipolar sealer system for electrocoagulation is effective in Total Knee Arthroplasty in reducing the visible total blood loss until drain removal on day two ...
Pfeiffer, Michael, Bräutigam, Heike, Draws, Detlev, Sigg, Andreas   +3 more
doaj  

Cardiac arrest due to massive hemorrhage from uterine adenomyosis with leiomyoma successfully treated with damage control resuscitation

Acute Medicine & Surgery, 2016
Case A 57‐year‐old woman was transferred to our emergency department by ambulance with cardiopulmonary arrest caused by massive genital bleeding. Cardiopulmonary resuscitation, including massive transfusion, was carried out and the return of spontaneous ...
Takeshi Yagi, Motoki Fujita, Tomoaki Inoue, Mari Otsuji, Yasutaka Koga, Takashi Nakahara, Takashi Miyauchi, Kotaro Kaneda, Yasutaka Oda, Ryosuke Tsuruta   +9 more
doaj   +1 more source

Reanalysis of Agelietti Procedure (A Method of Corrective Supracondylar Femoral Osteotomy) [PDF]

, 2012
Objective: Supracondylar femoral osteotomy is the time tested method, used for correcting the angular (varus & valgus) deformities at the knee. Traditionally, Coventry type of osteotomy where a medial or lateral based wedge of bone is removed or an open ...
Agarwal, S
core   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Acido tranexâmico e hemostasia em cirurgia de revascularização do miocárdio com circulação extracorpórea Tranexamic acid and hemostasis in myocardial revascularization with extracorporeal circulation

Brazilian Journal of Cardiovascular Surgery, 1992
O antífibrinolítico sintético ácido tranexâmico (Transamin ®) foi avaliado em seus efeitos hemostáticos e poupadores de transfusões homólogas, em pacientes submetidos a revascularização do miocárdio com circulação extracorpórea (CEC).
Guilherme F Vargas, João Nelson R Branco, Ana Hercília S Guimarães, Cecília Kobata, Espedito T. V. F Silva, Carlos Alberto Teles, Carlos Arnulfo A La Rotta, M. L. A Batista Filho, José Carlos S Andrade, Ênio Buffolo   +9 more
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