Results 71 to 80 of about 760,144 (313)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Surgical complications after robotic thyroidectomy for thyroid carcinoma: a single center experience with 3,000 patients

, 2014
BACKGROUND: Robotic thyroidectomy (RT), a new gasless, transaxillary approach developed by the Yonsei University group in Seoul, Korea, eliminates the need for a cervical incision.
이소희, 남기현, 박정수, 정웅윤, 김원웅, 박슬기, 정종주, 유지영, 반은정, 강상욱, 손해영, 이초록   +11 more
core   +1 more source

Can better surgical outcomes be obtained in the learning process of robotic rectal cancer surgery? A propensity score-matched comparison between learning phases

, 2021
Background: Although studies of robotic rectal cancer surgery have demonstrated the effects of learning on operation time, comparisons have failed to demonstrate differences in clinicopathological outcomes between unadjusted learning phases.
김남규, 한윤대, 양승윤, 이강영, 허혁, 조민수, 민병소, 이종민   +7 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The role of costal cartilage in musculoskeletal regeneration: A systematic review

Journal of Experimental Orthopaedics
Purpose Musculoskeletal tissue regeneration remains a major clinical challenge due to the limited intrinsic healing capacity of cartilage, bone and interface tissues, as well as the complexity of recreating their hierarchical structure and mechanical ...
Francesca Veronesi, Luca Cavazza, Leonardo Vivarelli, Marta Pluchino, Gianluca Giavaresi, Dante Dallari, Marco Govoni   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Surgical techniques for the management of a dislocated posterior chamber intraocular lens

, 2007
Posterior chamber intraocular lens (PC-IOL) dislocation occurs due to suboptimal posterior capsule support. Subluxated PC-IOLs involve more extensive dislocation, generally with an open pupillary space, but with the IOL lodged in the anterior vitreous ...
Smiddy, William E, Flynn, Harry, Flynn Jr, Harry W   +2 more
core   +1 more source

Following-Up Micro-Rheological and Microcirculatory Alterations During the Early Wound Healing Phase of Local and Rotated Musculocutaneous Flaps in Rats

Life
In reconstructive surgery, usage of different flaps is essential to cover tissue defects. Twisting, stretching or damaging the vascular pedicle may jeopardize the flaps’ viability.
Gergo Kincses, Laszlo Adam Fazekas, Adam Varga, Adam Attila Matrai, Nguyen Xuan Loc, Kincso Barabasi, Anna Orsolya Flasko, Tamas Juhasz, Abel Molnar, Norbert Nemeth   +9 more
doaj   +1 more source