Results 71 to 80 of about 133,335 (273)

Efficient online quantum circuit learning with no upfront training

Communications Physics
Optimization is a promising candidate for studying the utility of variational quantum algorithms (VQAs). However, evaluating cost functions using quantum hardware introduces runtime overheads that limit exploration.
Tom O’Leary, Piotr Czarnik, Elijah Pelofske, Andrew T. Sornborger, Michael McKerns, Lukasz Cincio   +5 more
doaj   +1 more source

Enhancing Cooperative Coevolution for Large Scale Optimization by Adaptively Constructing Surrogate Models

, 2018
It has been shown that cooperative coevolution (CC) can effectively deal with large scale optimization problems (LSOPs) through a divide-and-conquer strategy.
Chen, An, Liang, Yongsheng, Pang, Bei, Ren, Zhigang   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Variable-fidelity optimization of microwave filters using co-kriging and trust regions [PDF]

, 2012
In this paper, a variable-fidelity optimization methodology for simulation-driven design optimization of filters is presented. We exploit electromagnetic (EM) simulations of different accuracy.
Couckuyt, Ivo, Dhaene, Tom, Koziel, Slawomir   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Gradient Enhanced Efficient Global Optimization-Driven Aerodynamic Shape Optimization Framework

Aerospace
The aerodynamic optimization of airfoil shapes remains a critical research area for enhancing aircraft performance under various flight conditions.
Niyazi Şenol, Hasan U. Akay, Şahin Yiğit   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimal location of cutoff walls for seawater intrusion

Applied Water Science, 2021
In this paper, the simulation–optimization method is used to study the optimal location of cutoff walls for seawater intrusion. The optimization model is based on minimizing the chlorine concentration of two water sources after 50 years.
Han Zheng, Lu Wenxi, Fan Yue, Miao Tiansheng, Lin Jin, Li Jiuhui   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source