Results 11 to 20 of about 53,197 (261)

The perils of surrogate endpoints [PDF]

European Heart Journal, 2015
Our goals in medicine are (i) to improve the quality of patients' lives, (ii) help them to live longer, and (iii) to do so at a reasonable cost. These are our true endpoints: health status, survival, and cost. It is thus entirely consistent with this point of view that these are the fundamental concepts that can be united in a formal cost–utility ...
Weintraub, William S, Lüscher, Thomas F, Pocock, Stuart   +2 more
openaire   +4 more sources

The Relationship Between Short-Term Surrogate Endpoint Indicators and mPFS and mOS in Clinical Trials of Malignant Tumors: A Case Study of Approved Molecular Targeted Drugs for Non-Small-Cell Lung Cancer in China

Frontiers in Pharmacology, 2022
Objective: Due to the initiation of the priority review program in China, many antitumor drugs have been approved for marketing based on phase II clinical trials and short-term surrogate endpoint indicators.
Mingjun Rui, Mingjun Rui, Zijing Wang, Zijing Wang, Zhengyang Fei, Zhengyang Fei, Yao Wu, Yao Wu, Yingcheng Wang, Yingcheng Wang, Lei Sun, Ye Shang, Ye Shang, Hongchao Li, Hongchao Li   +14 more
doaj   +1 more source

Surrogate endpoint evaluation using data from one large global randomized controlled trial

BMC Medical Informatics and Decision Making, 2021
Background Robust identification of surrogate endpoints can help accelerate the development of pharmacotherapies for diseases traditionally evaluated using true endpoints associated with prolonged follow-up.
Milan Geybels, Benjamin Ole Wolthers, Frederik Flindt Kreiner, Søren Rasmussen, Robert Bauer   +4 more
doaj   +1 more source

Intermediate endpoints as surrogates for outcomes in cancer immunotherapy: a systematic review and meta-analysis of phase 3 trialsResearch in context

EClinicalMedicine, 2023
Summary: Background: Cancer immunotherapy shows unique efficacy kinetics that differs from conventional treatment. These characteristics may lead to the prolongation of trial duration, hence reliable surrogate endpoints are urgently needed.
Zhishan Zhang, Qunxiong Pan, Mingdong Lu, Bin Zhao   +3 more
doaj   +1 more source

Progression-Free Survival as Early Efficacy Endpoint in Resectable Esophageal Cancer Treated With Neoadjuvant Therapy: A Systematic Review

Frontiers in Oncology, 2022
To investigate literature-based evidence regarding progression-free survival (PFS) as an early efficacy endpoint in patients with resectable esophageal or gastroesophageal junction (GEJ) cancer receiving neoadjuvant therapy, this study identified large ...
Jie Zhu, Jie Zhu, Jin Tao, Zhen Dai, Yan Tan, Yan Tan, Li Jiang, Li Jiang, Qifeng Wang, Qifeng Wang, Jinyi Lang, Jinyi Lang   +11 more
doaj   +1 more source

A perfect correlate does not a surrogate make

BMC Medical Research Methodology, 2003
Background There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints between randomization groups ...
Kramer Barnett S, Baker Stuart G
doaj   +1 more source

Searching for potential surrogate endpoints of overall survival in clinical trials for patients with prostate cancer

Cancer Reports, 2021
Background The purpose of this study was to investigate the correlation between overall survival (OS) and other clinical outcomes in patients with prostate cancer. Further, we conducted subgroup analysis in the correlation of OS.
Hideki Maeda, Kentaro Takeda, Hisashi Urushihara, Tatsuo Kurokawa   +3 more
doaj   +1 more source

Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome [PDF]

Kidney Research and Clinical Practice, 2021
Backgrounds Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes.
Kipyo Kim, Eunji Baek, Suryeong Go, Hyung-Eun Son, Ji-Young Ryu, Yongjin Yi, Jong Cheol Jeong, Sejoong Kim, Ho Jun Chin   +8 more
doaj   +1 more source

Scoping and targeted reviews to support development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: protocol

BMJ Open, 2022
Introduction Using a surrogate endpoint as a substitute for a primary patient-relevant outcome enables randomised controlled trials (RCTs) to be conducted more efficiently, that is, with shorter time, smaller sample size and lower cost. However, there is
Derek Stewart, Rod Taylor, Christopher Weir, Oriana Ciani, Philippa Davies, Anthony Muchai Manyara, Valerie Wells   +6 more
doaj   +1 more source

Biomarkers and surrogate endpoints [PDF]

British Journal of Clinical Pharmacology, 2005
When David Beckham leaves the field towards the end of a match, the man who replaces him is a surrogate. and although I suspect that many footballers, if asked, would say that Surrogate is a town in Yorkshire, the word actually comes from the Latin word subrogare, to substitute.
openaire   +3 more sources