Results 191 to 200 of about 82,696 (289)

A surrogate endpoint-based provisional approval causal roadmap, illustrated by vaccine development. [PDF]

Biostatistics
Gilbert PB, Peng J, Han L, Lange T, Lu Y, Nie L, Shih MC, Waddy SP, Wiley K, Yann M, Zafari Z, Ghosh D, Follmann D, Juraska M, Díaz I.   +14 more
europepmc   +1 more source

Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study. [PDF]

BMJ Open, 2021
Aubert O, Divard G, Pascual J, Oppenheimer F, Sommerer C, Citterio F, Tedesco H, Chadban S, Henry M, Vincenti F, Srinivas T, Watarai Y, Legendre C, Bernhardt P, Loupy A.   +14 more
europepmc   +1 more source

Biodegradable and Recyclable Luminescent Mixed‐Matrix‐Membranes, Hydrogels, and Cryogels based on Nanoscale Metal‐Organic Frameworks and Biopolymers

Advanced Functional Materials, EarlyView.
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner, Julian Burkhart, Kateryna Borysova, Chiara Mazzariol, Klaus Müller‐Buschbaum   +4 more
wiley   +1 more source

Relapse-Free Survival (Rfs) As a Surrogate Endpoint for Overall Survival (Os) in Adjuvant Interferon Trials in Patients (Pts) with Resectable Cutaneous Melanoma: an Individual Patient Data (Ipd) Meta-Analysis [PDF]

, 2014
Stefan Suciu, Alexander M.M. Eggermont, Paul Lorigan, John M. Kirkwood, S. N. Markovic, Claus Garbe, David Cameron, S. Kotapati, Cyril Konto, Tiandong Chen, Keith Wheatley, Natalie Ives, Gaetan de Schaetzen, Achmad Efendi, Marc Buyse   +14 more
openalex   +1 more source

Beyond the Beam: Exploring Charged Particle Nanoprinting

Advanced Functional Materials, EarlyView.
Charged particle nanoprinting using electrons and ions is highly advanced, offering great potential for research and industry. However, challenges in precursor design and process optimization persist, but also offer great opportunities to drive nanofabrication innovations.
Nicolas Paul Jochmann, Alba Salvador‐Porroche, Sven Barth   +2 more
wiley   +1 more source

Comment on "Evaluating pathological complete response as an surrogate endpoint for long-term survival in patients with non-small cell lung cancer: a systematic review and meta-analysis". [PDF]

Int J Surg
Ding N, Chen T, Chen Y.
europepmc   +1 more source

Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH-ASBMR SABRE Project. [PDF]

J Bone Miner Res, 2022
Eastell R, Vittinghoff E, Lui LY, McCulloch CE, Pavo I, Chines A, Khosla S, Cauley JA, Mitlak B, Bauer DC, Bouxsein M, Black DM.   +11 more
europepmc   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

Evaluating Minimal Residual Disease Negativity as a Surrogate Endpoint for Treatment Efficacy in Multiple Myeloma: A Meta-Analysis of Randomized Controlled Trials. [PDF]

Am J Hematol
Ntanasis-Stathopoulos I, Filippatos C, Ntanasis-Stathopoulos A, Malandrakis P, Kastritis E, Tsitsilonis OE, Dimopoulos MA, Terpos E, Gavriatopoulou M.   +8 more
europepmc   +1 more source

Neuronal cell death and axonal degeneration: Neurofilaments as biomarkers. [PDF]

, 2009
Petzold, A
core